Go to
JCI Insight
Citations to this article
Abstract
The effects of administered human growth hormone (HGH) were evaluated in dwarfed, prepubertal children who were receiving long-term corticosteroid therapy for a chronic disease. During 11 complete metabolic balance studies, the eight corticosteroid-treated children demonstrated impaired response to large doses of HGH with minimal nitrogen and no phosphorus retention. In contrast, two hypopituitary subjects and two asthmatic children not receiving corticosteroid responded to the same preparations of HGH with nitrogen, potassium, and phosphorus retention. Six corticosteroid-treated children were given large doses of HGH (40-120 mg/wk for 4 to 8 months and showed no improvement in their retarded rate of growth, whereas the hypopituitary subjects showed accelerated growth during administration of 10-15 mg of HGH/wk. It is concluded that dwarfism in steroid-treated children results from corticosteroid-induced antagonism of the effects of HGH at the peripheral tissue level.
Authors
Helen G. Morris, Jacqueline R. Jorgensen, Harold Elrick, Richard E. Goldsmith
Total citations by year
Citation information
Citations to this article (70)
| Title and authors | Publication | Year |
|---|---|---|
|
Astragalus Extract Mixture HT042 Alleviates Dexamethasone-Induced Bone Growth Retardation in Rat Metatarsal Bones
Baek CY, Lee J, Lee D, Kim H |
Nutrients | 2024 |
|
Textbook of Pediatric Rheumatology
E Silverman, J Buyon, E Jaeggi |
Textbook of Pediatric Rheumatology | 2016 |
|
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
|
Sexual maturation in Moroccan patients with juvenile idiopathic arthritis
DE Badri, S Rostom, I Bouaddi, A Hassani, B Chkirate, B Amine, N Hajjaj-Hassouni |
Rheumatology International | 2013 |
|
PHARMACOLOGY AND DRUG THERAPY
NT Ilowite, RM Laxer |
Textbook of Pediatric Rheumatology | 2011 |
|
Corticosteroid minimization after renal transplantation : Letter to the editors
D Cantarovich |
Transplant International | 2011 |
|
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
GROWTH SUPPRESSION BY GLUCOCORTICOID THERAPY
DB Allen |
Endocrinology & Metabolism Clinics of North America | 1996 |
|
Endocrine aspects of paediatric rheumatic diseases
G Neeck, H Michels |
Baillière's Clinical Rheumatology | 1996 |
|
Growth hormone is not able to counteract osteopenia of rat cortical bone induced by Glucocorticoid with protracted effect
G Ørtoft, A Brüel, TT Andreassen, H Oxlund |
Bone | 1995 |
|
Childhood asthma and growth—a review of the literature
G Russell |
Respiratory Medicine | 1994 |
|
The utility of parenteral glucocorticoids in the emergency department
KD Hoang, CV Pollack |
The Journal of Emergency Medicine | 1994 |
|
Asthma and growth
G Russell |
Archives of disease in childhood | 1993 |
|
Recent Progress in Hormone Research
BM Lippe, JM Nakamoto |
Recent Progress in Hormone Research | 1993 |
|
Effects of growth hormone administration in pediatric renal allograft recipients
S Bartosh, B Kaiser, I Rezvani, M Polinsky, S Schulman, JA Palmer, HJ Baluarte |
Pediatric Nephrology | 1992 |
|
The Untoward Effects of Steroid Treatment on the Musculoskeletal System and What to Do About Them
JR Hollister |
Journal of Asthma | 1992 |
|
Steroid complications in patients with ulcerative colitis
M Kusunoki, G Möeslein, Y Shoji, S Fujita, H Yanagi, Y Sakanoue, N Saito, J Utsunomiya |
Diseases of the Colon & Rectum | 1992 |
|
Comparison of growth retarding effects induced by two different glucocorticoids in prepubertal sick children: An interim long-term analysis
G Aicardi, S Milani, B Imbimbo, M Vignolo, E Battista, R Gusmano, A Terragna, G Cordone, F Cottafava, R Coppo, O Sernia, MG Porcellini, ML Sardella, M Barottø, L Benso |
Calcified Tissue International | 1991 |
|
Comparison of growth retarding effects induced by two different glucocorticoids in prepubertal sick children: An interim long-term analysis
G Aicardi, S Milani, B Imbimbo, M Vignolo, ED Battista, R Gusmano, A Terragna, G Cordone, F Cottafava, R Coppo, O Sernia, MG Porcellini, ML Sardella, M Barottø, L Benso |
Calcified Tissue International | 1991 |
|
Growth in Allergic Children
D Solé, AM Castro, CK Naspitz |
Journal of Asthma | 1989 |
|
Incidence of Osteonecrosis in Asthmatic Children on Long-Term Steroids
RN Irani, TM Kain, AR Rooklin, HE MANSMANN, E O'hara, CH Park |
Pediatric Asthma, Allergy & Immunology | 1989 |
|
Corticosteroids and growth
JS Hyams, DE Carey |
The Journal of Pediatrics | 1988 |
|
Relationship of type I procollagen to corticosteroid therapy in children with inflammatory bowel disease
JS Hyams, RE Moore, AM Leichtner, DE Carey, BD Goldberg |
The Journal of Pediatrics | 1988 |
|
Basic and Clinical Aspects of Growth Hormone
BB Bercu |
1988 | |
|
The Adrenal Gland
CR Kannan |
1988 | |
|
The Pituitary Gland
CR Kannan |
1987 | |
|
Control and Manipulation of Animal Growth
V Oddy, D Lindsay |
Control and Manipulation of Animal Growth | 1986 |
|
7 Somatomedin activity in disorders of nutrition and metabolism
LS Phillips, TG Unterman |
Clinics in Endocrinology and Metabolism | 1984 |
|
Effect of different corticosteroid regimens on hypothalamic-pituitary-adrenal axis and growth in juvenile chronic arthritis
MA Byron, J Jackson, BM Ansell |
Journal of the Royal Society of Medicine | 1983 |
|
Corticosteroids in the Treatment of Allergic Disease: Principles and Practice
GG Shapiro |
Pediatric Clinics of North America | 1983 |
|
Potent Interaction Between Glucocorticoids and Growth Hormone-Releasing Factor in Vivo
WB Wehrenberg, A Baird, N Ling |
Science | 1983 |
|
Prednisolone effects upon body and organ weights, water intake, and several behaviors
RG Sewell, JA Gallus, KP Nanry |
Pharmacology Biochemistry and Behavior | 1982 |
|
Disorders of Mineral Metabolism
RK Rude, FR Singer |
Disorders of Mineral Metabolism | 1982 |
|
Growth in Children with Renal Insufficiency
M Broyer |
Pediatric Clinics of North America | 1982 |
|
Mechanisms of activation of renal (Na+ + K+)-ATPase in the rat Effects of acute and chronic administration of dexamethasone
SK Sinha, HJ Rodriguez, WC Hogan, S Klahr |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1981 |
|
The responses of the developing endocrine system to hormones and drugs
G Telegdy |
Pharmacology & Therapeutics | 1980 |
|
Mechanisms of glucocorticoid inhibition of growth
JD Baxter |
Kidney International | 1978 |
|
An approach to solving problems of growth retardation in the child and teenager
RG McArthur, JE Fagan |
Canadian Medical Association journal | 1977 |
|
Appraisals of Cromolyn Sodium and Corticosteroids in the Treatment of the Asthmatic Child
HI Lecks |
Clinical Pediatrics | 1977 |
|
Diabetes mellitus • B
R Beckmann, M Berger, A Beringer, P Berchtold, J Beyer, A Bischoff, G Brehm, BF Clarke, GR Constam, LJ Duncan, FA Gries, A Hasselblatt, R Hild, K Irmscher, K Jahnke, J Kühnau, H Liebermeister, K Lundbaek, G Meyer-Schwickerath, S Napp-Mellinghoff, M Neubauer, F Nobbe, K Oberdisse, P Petrides, R Petzoldt, H Sauer, K Schöffling, M Spitznas, J Steinke, M Vogel, KH Vogelberg, A Wessing |
1977 | |
|
Cortisol in physiological concentrations acts within minutes to modify effects of prolactin and growth hormone on prostaglandin secretion: Importance of effect in modulating cellular responses to calcium and cyclic nucleotides
DF Horrobin, JP Mtabaji, MS Manku |
Medical Hypotheses | 1976 |
|
Corticosteroids and Growth
JN Loeb |
New England Journal of Medicine | 1976 |
|
Growth hormone deficiency in children with brain tumors
SM Shalet, CG Beardwell, P Morris-Jones, FN Bamford, GG Ribeiro, D Pearson |
Cancer | 1976 |
|
Adipositas
FA Gries, P Berchtold, M Berger |
1976 | |
|
The effect of administered corticosteroids on the growth of children
MA Preece |
Postgraduate medical journal | 1976 |
|
Mechanism of action of glucocorticoids
EB Thompson, ME Lippman |
Metabolism | 1974 |
|
Diurnal Variation in the Responsiveness of Human Subjects to Human Growth Hormone
D Rudman, D Friedes, JH Patterson, DL Gibbas |
Journal of Clinical Investigation | 1973 |
|
Growth Hormone Secretion in Children Part II: The responses of growth hormone secretion with insulin induced hypoglycemia in various diseases
F Komatsu |
Pediatrics International | 1973 |
|
Pediatric Uses of Steroids
GE Bacon, ML Spencer |
Medical Clinics of North America | 1973 |
|
Human Growth Hormone
JM Tanner |
Nature | 1972 |
|
Cushing's syndrome in childhood
DW Killinger, RW Hudson, R Volpé |
Canadian Medical Association journal | 1972 |
|
Effect of cortisone therapy on the diurnal pattern of growth hormone secretion in congenital adrenal hyperplasia
AM Vazquez, JC Schutt-Aine, FM Kenny, C Richards, D Anthony |
The Journal of Pediatrics | 1972 |
|
Apparent cure of Cushing's disease by bilateral adrenalectomy and autotransplantation
NM Kaplan, GT Shires |
The American Journal of Medicine | 1972 |
|
Diagnosis and management of hypopituitarism
R Hall |
Journal of the Royal College of Physicians of London | 1972 |
|
SYSTEMIC CORTICOSTEROID THERAPY
JR Turtle |
The Medical Journal of Australia | 1972 |
|
Observations on the responsiveness of human subjects to human growth hormone Effects of endogenous growth hormone deficiency and myotonic dystrophy
D Rudman, SB Chyatte, JH Patterson, GG Gerron, I O'Beirne, J Barlow, P Ahmann, A Jordan, RC Mosteller |
Journal of Clinical Investigation | 1971 |
|
Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth
DW Zutshi, M Friedman, BM Ansell |
Archives of disease in childhood | 1971 |
|
Adverse effects of large doses ofmedroxyprogesterone (MPA) in idiopathic isosexual precocity
RA Richman, LE Underwood, FS French, JJ van Wyk |
The Journal of Pediatrics | 1971 |
|
Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens
RA Sturge, C Beardwell, M Hartog, D Wright, BM Ansell |
British medical journal | 1970 |
|
Adrenal glucocorticoids after twenty years
DS David, MH Grieco, P Cushman |
Journal of Chronic Diseases | 1970 |
|
Effect of glucocorticoids on plasma growth hormone in man
JN Stiel, DP Island, GW Liddle |
Metabolism | 1970 |
|
Nutrition and Endocrine Disease
RA Kreisberg, WC Owen, AM Siegal |
The Medical clinics of North America | 1970 |
|
Growth hormone secretion in growth-retarded asthmatic children
SS Sanders, AP Norman |
British medical journal | 1969 |
|
Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol
JR Hodges, J Sadow |
British Journal of Pharmacology | 1969 |
|
Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with Cortisol
JR Hodges, J Sadow |
British Journal of Pharmacology | 1969 |
|
Studies of the secretion and metabolic effects of human growth hormone in children with glucocorticoid-induced growth retardation
AW Root, AM Bongiovanni, WR Eberlein |
The Journal of Pediatrics | 1969 |
|
HUMAN GROWTH HORMONE AND HYPOPITUITARY GROWTH RETARDATION
O Trygstad |
Acta paediatrica (Oslo, Norway : 1992) | 1969 |
|
Regional Enteritis
DH Law |
Gastroenterology | 1969 |
|
Plasma growth hormone concentration in corticosteroid-treated children
HG Morris, JR Jorgensen, SA Jenkins |
Journal of Clinical Investigation | 1968 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)