Usage Information
Citation Information: J Clin Invest. 1968;47(2):329-335. https://doi.org/10.1172/JCI105728.
Abstract
Glucose titration studies were performed in normal rats under control conditions and during expansion of the extracellular fluid volume. In association with expansion, the maximal rate of glucose transport (Tmglucose) decreased while glomerular filtration rate (GFR) typically increased; thus there was a consistent increase in the GFR/Tmglucose ratio. In previous studies, marked reduction of the nephron population was associated with an alteration in the kinetics of glucose transport and GFR/Tmglucose ratios were observed to increase. In both volume-expanded rats and in animals and human beings with uremia, the splay in the titration curve is increased. Finally in both volume-expanded animals and uremic animals fractional reabsorption of sodium is depressed. One interpretation of the present data is that the natriuretic “third factor” may influence a key rate-limiting step in glucose transport; and it is possible that this step is shared by or coupled to a rate-limiting step in sodium transport.
Authors
Alan M. Robson, Prem L. Srivastava, Neal S. Bricker
Usage data is cumulative from January 2024 through January 2025.
| Usage | JCI | PMC |
|---|---|---|
| Text version | 89 | 0 |
| 64 | 16 | |
| Scanned page | 250 | 3 |
| Citation downloads | 55 | 0 |
| Totals | 458 | 19 |
| Total Views | 477 | |
Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.
Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)