Sera from patients with extrahepatic biliary obstruction were found to have an abnormal lipoprotein (obstructive lipoprotein) which failed to react with antibodies to normal lipoproteins of d < 1.063. Preparations of this abnormal lipoprotein made by a combination of immunoprecipitation and multiple polyanion precipitations revealed a high content of free cholesterol (26%) and phospholipids (61%) but only trace amounts of cholesterol esters and triglycerides. Protein content varied from 13% to a corrected low of 5% when ultracentrifugation was also performed. Amino acid analyses of the latter preparations resembled that of lipoproteins of d < 1.006.
Sam Switzer
Title and authors | Publication | Year |
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Lipoprotein-X fifty years after its original discovery
R Fellin, E Manzato |
Nutrition, Metabolism, and Cardiovascular Diseases | 2019 |
Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis
T Watanabe, T Nema, N Hiruta, T Murano, WJ Schneider, H Bujo |
Journal of Clinical Lipidology | 2018 |
Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia
KM Stepien, H Divyateja, F Ahmed, P Prinsloo, P Gupta |
Annals of Clinical Biochemistry | 2013 |
Laboratory Testing for Liver Disease
T Poynard, F Imbert-Bismut |
Zakim and Boyer s Hepatology | 2012 |
Anomalous lipoprotein-X in type 2 diabetes mellitus
MR Ovsepian, MG Ébragimzade, AB Gabrielian, MG Oganesian, AA Gevorkian, AA Mamikonian, AS Boiadzhian |
Problems of Endocrinology | 2012 |
Advances in Clinical Chemistry
M Mahler |
Advances in Clinical Chemistry Volume 54 | 2011 |
Unusual severe hypercholesterolaemia and xanthomas in a patient with hepatolithiasis
SC Chou, KW Chen, JD Lin, TL Hwang |
HOSP MED | 2004 |
EVALUATION OF TESTS USED TO SCREEN PATIENTS WITH LIVER DISORDERS
R Scheig |
Primary Care Clinics in Office Practice | 1996 |
Metabolism of cholesterol and low- and high-density lipoproteins in primary biliary cirrhosis: Cholesterol absorption and synthesis related to lipoprotein levels and their kinetics
H Gylling, M Färkkilä, M Vuoristo, TA Miettinen |
Hepatology | 1995 |
Lipoprotein-X fails to inhibit hydroxymethylglutaryl coenzyme A reductase in HepG2 cells
CM Edwards, MP Otal, PW Stacpoole |
Metabolism | 1993 |
5 Dyslipoproteinaemia of liver disease
JP Miller |
Baillière's Clinical Endocrinology and Metabolism | 1990 |
Serum lipids and gallstones: A case-control study
C Thijs, P Knipschild, P Brombacher |
Gastroenterology | 1990 |
High density lipoprotein particle size distribution in subjects with obstructive jaundice
PM Clifton, PJ Barter, AM Mackinnon |
Journal of lipid research | 1988 |
Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts
KJ Williams, AR Tall, I Tabas, C Blum |
Journal of lipid research | 1988 |
Inhibition of hepatic triglyceride secretion and exogenous triglyceride clearance in the cholestatic rat
K Komai, SM Sabesin, SW Weidman |
Atherosclerosis | 1987 |
Cholesterol-phospholipid vesicles in human bile: an ultrastructural study
GJ Sömjen, Y Marikovsky, P Lelkes, T Gilat |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Xanthomas and hyperlipidemias
F Parker |
Journal of the American Academy of Dermatology | 1985 |
Lipoprotein abnormalities in primary biliary cirrhosis
CE Jahn, EJ Schaefer, LA Taam, JH Hoofnagle, FT Lindgren, JJ Albers, EA Jones, HB Brewer |
Gastroenterology | 1985 |
Increased concentration of high density lipoprotein in plasma and decreased platelet aggregation in primary biliary cirrhosis
Y Baruch, JG Brook, S Eidelman, M Aviram |
Atherosclerosis | 1984 |
Biliary lipid metabolism in children with chronic intrahepatic cholestasis
M Becker, K von Bergmann, HW Rotthauwe, O Leiss |
European Journal of Pediatrics | 1984 |
A novel assay for the quantitative determination of lipoprotein-X (LP-X) in serum
ES Bos, AA van der Doelen, AE Denissen, BC Goverde, HN Magnani, GM Kostner |
Clinica Chimica Acta | 1983 |
Die Bedeutung des Lipoprotein-X-Cholesterins in der Differentialdiagnostik der Cholestase
H Wieland, H Meissner-Heins, C Heins, D Seidel |
Klinische Wochenschrift | 1982 |
Abnormalities of erythrocyte stromal lipids in atresia of the intrahepatic bile ducts
S Chapelle, C Franclois, JM Chantraine |
Archives Of Physiology And Biochemistry | 1982 |
Properties of Lipoproteins in Blood Plasma and Liver Perfusates of Rats With Cholestasis
TE Felker, RL Hamilton, JL Vigne, RJ Havel |
Gastroenterology | 1982 |
Increased serum low-density lipoprotein cholesterol in men treated short-term with the diuretic chlorthalidone
Z Glück, P Weidmann, R Mordasini, C Bachmann, W Riesen, E Peheim, G Keusch, A Meier |
Metabolism | 1980 |
Verhandlungen der Deutschen Gesellschaft für innere Medizin
B Schlegel |
1980 | |
Effect of serum lipoproteins of bile obstructed rats on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in perfused rat liver
AJ Barak, MF Sorrell, DJ Tuma |
Lipids | 1979 |
Age-related changes in rat and primate plasma cholesterol metabolism
A G Lacko, J L Davis |
Journal of the American Geriatrics Society | 1979 |
Lipoprotein-X
S Narayanan, D Seidel |
Critical Reviews in Clinical Laboratory Sciences | 1979 |
Influence of increased membrane cholesterol on membrane fluidity and cell function in human red blood cells
RA Cooper |
Journal of Supramolecular Structure | 1978 |
Rapid colorimetric methods for quantitative lipoprotein-X determination without electrophoresis
E Talafant, J Továrek |
Clinica Chimica Acta | 1978 |
Influence of bile acids and free fatty acids on physicochemical properties of LP-X
G Baggio, P Müller, H Wieland, PD Niedmann, D Seidel |
Research in Experimental Medicine | 1978 |
Lipoprotein-X and diagnosis of cholestasis: Comparison with other biochemical parameters and liver biopsy
R Fellin, E Manzato, S Zotti, G Baggio, G Briani, M Rugge |
Clinica Chimica Acta | 1978 |
Changes in rat serum lipoproteins following ligation of the bile duct
RH Hinton, BM Mullock |
Clinica Chimica Acta | 1978 |
Plasma lipids and lipoproteins in liver disease
N McIntyre |
Gut | 1978 |
Excretory Liver Function Tests
J Bircher, R Preisig |
1978 | |
Studien zur Charakterisierung und zum Stoffwechsel des Lipoprotein-X (LP-X), des abnormen Lipoproteins der Cholestase
D Seidel |
Klinische Wochenschrift | 1977 |
Secondary hypertriglyceridaemia in patients with parenchymal liver disease
G Klose, J Windelband, A Weizel, H Greten |
European Journal of Clinical Investigation | 1977 |
The Lipid Bilayer Structure of the Abnormal Human Plasma Lipoprotein X. An X-Ray Small-Angle-Scattering Study
P LAGGNER, O GLATTER, K MULLER, O KRATKY, G KOSTNER, A HOLASEK |
European Journal of Biochemistry | 1977 |
Effect of lipoprotein-X on hepatic cholesterol synthesis
M Liersch, G Baggio, CC Heuck, D Seidel |
Atherosclerosis | 1977 |
Lipoprotein-X: a substrate for lecithin: cholesterol acyltransferase
JR Patsch, AK Soutar, JD Morrisett, AM Gotto, LC Smith |
European Journal of Clinical Investigation | 1977 |
Effect of electrical brain stimulation on erythrocyte membrane lipids
F Parl, LK Bjornson, G Kiu, WH Gutstein |
Life Sciences | 1977 |
Plasma lipoprotein changes in experimental cholestasis in the dog
B Danielsson, R Ekman, BG Johansson, BG Petersson |
Clinica Chimica Acta | 1977 |
Abnormal Plasma Lipoproteins and Lecithin-Cholesterol Acyltransferase Deficiency in Alcoholic Liver Disease
SM Sabesin, HL Hawkins, L Kuiken, JB Ragland |
Gastroenterology | 1977 |
Isolation, chemical characterization, and biophysical properties of three different abnormal lipoproteins: LP-X1, LP-X2, and LP-X3
JR Patsch, KC Aune, AM Gotto, JD Morrisett |
The Journal of biological chemistry | 1977 |
Formation of lipoprotein-X. Its relationship to bile compounds
E Manzato, R Fellin, G Baggio, S Walch, W Neubeck, D Seidel |
Journal of Clinical Investigation | 1976 |
Effect of bile salts on the hepatic regulation of serum lecithin: cholesterol acyltransferase activity
KJ Ho, R Cisternas, GS Boyd |
Atherosclerosis | 1976 |
The fusion of abnormal plasma lipoprotein (LP-X) and the erythrocyte membrane in patients with cholestasis studied by electronmicroscopy
AJ Verkleij, IL Nauta, JM Werre, JG Mandersloot, B Reinders, PH Ververgaert, J Gier |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1976 |
Investigation of the abnormal low-density lipoproteins occurring in patients with obstructive jaundice
GM Kostner, P Laggner, HJ Prexl, A Holasek |
Biochemical Journal | 1976 |
On the metabolism of lipoprotein-X (LP-X)
D Seidel, HU Büff, U Fauser, U Bleyl |
Clinica Chimica Acta | 1976 |
Isolation and partial characterization of two abnormal human plasma lipoproteins: LP-X1 and LP-X2
JR Patsch, W Patsch, S Sailer, H Braun-Steiner |
Biochimica et Biophysica Acta (BBA) - Protein Structure | 1976 |
Abnormal low density plasma lipoproteins occurring in dogs with obstructive jaundice
B Danielsson, R Ekman, BG Johansson, BG Petersson |
FEBS Letters | 1976 |
Fettstoffwechsel
G Assmann, J Augustin, E Baraona, HU Benz, W Brech, WV Brown, RJ Desnick, WR Fallat, S Ford, D Fredrickson, CJ Glueck, H Greten, K Harzer, P Herbert, GM Kostner, W Krivit, RI Levy, CS Lieber, M Liersch, G Middelhoff, GL Mills, NB Myant, RF ODea, J Papenberg, H Pilz, HM Rauen, S Sailer, G Schettler, G Schlierf, H Schriewer, D Seidel, J Slack, E Stange, O Stein, Y Stein, D Steinberg, A Weizel, H Wieland |
1976 | |
Immunochemical Studies of Lipoproteins in Cholestasis
R Ekman, BG Johansson, BG Petersson |
Scandinavian Journal of Immunology | 1975 |
Plasma lipoproteins in rats with experimental biliary obstruction, I. A chemical study
S Calandra, M Montaguti, V Cartoni, I Pasquali-Ronchetti |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1975 |
Bile Flow and Biliary Lipid Secretion Following Release of Biliary Obstruction in Man
L Lindblad, J Hammarsten, T Scherstén |
Scandinavian Journal of Gastroenterology | 1975 |
Quantitative Determination of the Abnormal Lipoprotein of Cholestasis, LP-X, in Liver Disease
S Ritland |
Scandinavian Journal of Gastroenterology | 1975 |
The Abnormal ‘Lipoprotein of Cholestasis’, Lipoprotein-X
S Ritland |
Scandinavian Journal of Gastroenterology | 1975 |
The hypercholesterolaemia of obstructive jaundice.
McIntyre N, Harry DS, Pearson AJ |
Gut | 1975 |
Serumlipoproteine bei akuter Virushepatitis
M Baumgarten, M Wienbeck, A Englhardt, GA Martini |
Klinische Wochenschrift | 1974 |
Rate of in vitro Incorporation of Precursors into Hepatic Lipids and Proteins in Patients with Extrahepatic Cholestasis
H Stakeberg, H Lundborg, T Scherstén |
European Journal of Clinical Investigation | 1974 |
Hypertriglyceridaemia Secondary to Liver Disease
P Müller, R Fellin, J Lambrecht, B Agostini, H Wieland, W Rost, D Seidel |
European Journal of Clinical Investigation | 1974 |
A method for quantitative determination of the abnormal lipoprotein of cholestasis, LP-X
S Ritland |
Clinica Chimica Acta | 1974 |
Properties of the abnormal human plasma lipoprotein (LP-X) characteristic of cholestasis after chemical modification with succinic anhydride
A Jonas, D Seidel |
Archives of Biochemistry and Biophysics | 1974 |
AUSTRALIA ANTIGEN IN URINE
G Scalise, MS Mura |
The Lancet | 1973 |
HEPATITIS-B ANTIGEN: IMMUNOLOGICAL RELATIONSHIP TO LP-X, THE ABNORMAL PLASMA-LIPOPROTEIN OF OBSTRUCTIVE JAUNDICE
AR Neurath, AM Prince, A Lippin, M Chen |
The Lancet | 1973 |
STUDIES OF LIPOPROTEIN-X (LP-X) AND BILE ACIDS IN FAMILIAL LCAT DEFICIENCY
E Gjone, NB Javitt, JP Blomhoff, O Fausa |
Acta Medica Scandinavica | 1973 |
Study of the abnormal lipoprotein-X in obstructive and non-obstructive jaundice
C Vergani, M Pietrogrande, MC Grondona |
Clinica Chimica Acta | 1973 |
Endoscopic Retrograde Choledocho-Pancreatography
RJ Burwood, GT Davies, BW Lawrie, LH Blumgart, PR Salmon |
Clinical Radiology | 1973 |
Isolation and characterization of lipoprotein-X (LP-X) from canine
P Müller, U Fauser, R Fellin, H Wieland, D Seidel |
FEBS Letters | 1973 |
Lecithin.cholesterol acyl-transferase and lipoprotein-X in liver disease
S Ritland, JP Blomhoff, E Gjone |
Clinica Chimica Acta | 1973 |
Separation of lipoprotein X and β-lipoprotein by zonal centrifugation or hydroxyapatite chromatography
B Danielsson, BG Johansson, BG Petersson |
Clinica Chimica Acta | 1973 |
Liquid crystalline lipid in the plasma of humans with biliary obstruction
SH Quarfordt, H Oelschlaeger, WR Krigbaum |
Journal of Clinical Investigation | 1972 |
An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver Disease
RA Cooper, MD Puray, P Lando, MS Greenverg |
Journal of Clinical Investigation | 1972 |
Identification of the abnormal cholestatic lipoprotein (LP-X) in familial lecithin:Cholesterol acyltransferase deficiency
H Torsvik, K Berg, HN Magnani, WJ McConathy, P Alaupovic, E Gjone |
FEBS Letters | 1972 |
Serum Cholesterol Esterification in Liver Disease. Combined Determinations of Lecithin: Cholesterol Acyltransferase and Lipoprotein-X
H Wengeler, H Greten, D Seidel |
European Journal of Clinical Investigation | 1972 |
A method for the quantitative determination of the abnormal lipoprotein (LP-X) of obstructive jaundice
HN Magnani, P Alaupović |
Clinica Chimica Acta | 1972 |
Further Aspects on the Characterization of High and Very Low Density Lipoproteins in Patients with Liver Disease
D Seidel, H Greten, HP Geisen, H Wengeler, H Wieland |
European Journal of Clinical Investigation | 1972 |
Structure of an abnormal plasma lipoprotein (LP-X) characterizing obstructive jaundice
D Seidel, B Agostini, P Müller |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1972 |
Lipoproteins in LCAT-deficiency
G Utermann, W Schoenborn, KH Langer, P Dieker |
Human Genetics | 1972 |
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins
KR Norum, JA Glomset, AV Nichols, T Forte |
Journal of Clinical Investigation | 1971 |
SERUM LIPOPROTEINS IN INFANTS WITH LIVER DISEASE
RF Leonard, JM Court, DM Danks |
Journal of Paediatrics and Child Health | 1971 |
Apoliproproteins and lipoproteins
P Alaupovic |
Atherosclerosis | 1971 |
A new immunochemical technique for a rapid, semi-quantitative determination of the abnormal lipoprotein (LP-X) characterizing cholestasis
D Seidel |
Clinica Chimica Acta | 1971 |
The Abnormal Lipoprotein of Cholestasis
RJ Havel |
New England Journal of Medicine | 1971 |
Cholestasis: Lamellar Structure of the Abnormal Human Serum Lipoprotein
RL Hamilton, RJ Havel, JP Kane, AE Blaurock, T Sata |
Science | 1971 |
A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins
D Seidel, P Alaupovic, RH Furman, WJ McConathy |
Journal of Clinical Investigation | 1970 |
XANTHOMATOSIS ASSOCIATED WITH HYPERLIPOPROTEINEMIA
F Parker, JM Short |
Journal of Investigative Dermatology | 1970 |
Cholesterinstoffwechsel und Lecithin-Cholesterin-Acyl-Transferase im Plasma bei experimenteller Hepatitis und Cholestase an der Ratte
R Kattermann, DI Wolfrum |
Clinical Chemistry and Laboratory Medicine | 1970 |
Abnormal Kinetics of Red Cell Membrane Cholesterol in Acanthocytes: Studies in Genetic and Experimental Abetalipoproteinaemia and in Spur Cell Anaemia
JA McBride, HS Jacob |
British Journal of Haematology | 1970 |
Amino acid composition of the serum low density lipoprotein in patients with familial lecithin:cholesterol acyltransferase deficiency
H Boman, H Torsvik |
Clinical Genetics | 1970 |
Amino acid composition of the serum low density lipoprotein in pactients with familial lecithin:cholesterol acyltransferase deficiency
H Boman, H Torsvik |
Clinical Genetics | 1970 |
A lipoprotein characterizing obstructive jaundice: isolation and analysis
RH Furman, D Seidel, P Alaupovic |
Transactions of the American Clinical and Climatological Association | 1970 |
Occurrence of an abnormal lipoprotein in patients with liver disease
A Ross, GM Murphy, PA Wilkinson, GL Mills, S Sherlock |
Gut | 1970 |
Vergleichende untersuchungen der lipoproteine des serums mit der agarosegel-elektrophorese und der disk-elektrophorese in polyacrylamid-gel
J Wollenweber, W Kahlke |
Clinica Chimica Acta | 1970 |
Serum Cholesterol Esterification in Liver Disease: Importance of Lecithin-Cholesterol Acyltransferase
JB Simon, R Scheig |
New England Journal of Medicine | 1970 |
Fortschritte in der Analyse der Plasmalipoproteine: Eine neue M�glichkeit zur Differentialdiagnose des Ikterus
D Seidel, P Alaupovic, RH Furman |
Klinische Wochenschrift | 1970 |
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
M Burstein, H Scholnick, R Morfin |
Journal of lipid research | 1970 |
A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects
D Seidel, P Alaupovic, RH Furman |
Journal of Clinical Investigation | 1969 |
Lipoproteins--a current perspective of methods and concepts
JL Oncley, NR Harvie |
Proceedings of the National Academy of Sciences | 1969 |
Ultracentrifugal characterization of a lipoprotein occurring in obstructive jaundice
GL Mills, D Seidel, P Alaupovic |
Clinica Chimica Acta | 1969 |
Identification of the protein moiety of an abnormal human plasma low-density lipoprotein in obstructive jaundice
P Alaupovic, D Seidel, WJ McConathy, RH Furman |
FEBS Letters | 1969 |
Synthesis of phospholipids and triglycerides in human liver slices. I. Experimental conditions and the synthesis rate in normal liver tissue
S Nilsson, T Scherstén |
Scandinavian Journal of Clinical & Laboratory Investigation | 1969 |
Protides of the Biological Fluids
PA Small, RH Waldman |
Protides of the Biological Fluids | 1969 |
Hereditary nonspherocytic hemolytic disease associated with an altered phospholipid composition of the erythrocytes
ER Jaffé, EL Gottfried |
Journal of Clinical Investigation | 1968 |
Advances in Lipid Research
AM Scanu |
Advances in Lipid Research | 1965 |