Citations to this article

Studies of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes: Increased Lysis and Lipid Peroxide Formation by Hydrogen Peroxide
Charles E. Mengel, … , Herbert E. Kann Jr., Wilhelm D. Meriwether
Charles E. Mengel, … , Herbert E. Kann Jr., Wilhelm D. Meriwether
Published November 1, 1967
Citation Information: J Clin Invest. 1967;46(11):1715-1723. https://doi.org/10.1172/JCI105662.
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Research Article

Studies of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes: Increased Lysis and Lipid Peroxide Formation by Hydrogen Peroxide

Abstract

When paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes were exposed to H2O2 they lysed excessively and formed greater than normal quantities of lipid peroxides when compared to red cells of normal subjects and patients with most types of hematologic disease. It was also shown that lytic sensitivity to acidified serum was related to the enhanced lytic sensitivity to H2O2. If the lipid of PNH cells was first extracted then exposed to ultraviolet radiation more lipid peroxides were formed than in extracts of normal red blood cells. The possible explanations for these findings and their relationship to the PNH hemolytic mechanism are discussed.

Authors

Charles E. Mengel, Herbert E. Kann Jr., Wilhelm D. Meriwether

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Citations to this article (43)

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