The Effects of Azathioprine (Imuran) on Purine Synthesis in Clinical Disorders of Purine Metabolism

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Abstract

Azathioprine, a purine analogue, significantly suppressed the purine synthesis de novo of two gouty patients manifesting overproduction of uric acid, as well as three of four gouty patients who showed normal uric acid production. This suppression is taken as evidence that phosphoribosyl-pyrophosphate amidotransferase, the rate-controlling step in purine synthesis de novo, has a normal sensitivity to feedback inhibitors in the patients who responded to the drug.

Authors

William N. Kelley, Frederick M. Rosenbloom, J. Edwin Seegmiller