Regional Myocardial Blood Flow

Jay M. Sullivan; Warren J. Taylor; William C. Elliott; Richard Gorlin

doi:10.1172/JCI105632

Cardiovascular Unit and Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts

‡

Formerly, Postdoctoral Fellow, National Heart Institute.

Instructor in Surgery, Harvard Medical School and Associate in Surgery, Peter Bent Brigham Hospital.

Instructor in Medicine, Harvard Medical School and Junior Associate in Medicine, Peter Bent Brigham Hospital.

Assistant Professor of Medicine, Harvard Medical School; Physician, Peter Bent Brigham Hospital; and Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. Richard Gorlin, 721 Huntington Avenue, Boston, Mass., 02215.

Submitted for publication 20 October 1966; accepted 1 June 1967.

Reported in part at annual meeting, American Heart Association, Bal Harbour, Fla., October 1965 (1).

This work was supported by U. S. Public Health Service grants HE 08591 and 1 TI 5679, and by a general research grant from the Ayerst Laboratories and Peter Bent Brigham Hospital.

Find articles by Sullivan, J. in: JCI | PubMed | Google Scholar

Cardiovascular Unit and Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts

‡

Formerly, Postdoctoral Fellow, National Heart Institute.

Instructor in Surgery, Harvard Medical School and Associate in Surgery, Peter Bent Brigham Hospital.

Instructor in Medicine, Harvard Medical School and Junior Associate in Medicine, Peter Bent Brigham Hospital.

Assistant Professor of Medicine, Harvard Medical School; Physician, Peter Bent Brigham Hospital; and Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. Richard Gorlin, 721 Huntington Avenue, Boston, Mass., 02215.

Submitted for publication 20 October 1966; accepted 1 June 1967.

Reported in part at annual meeting, American Heart Association, Bal Harbour, Fla., October 1965 (1).

This work was supported by U. S. Public Health Service grants HE 08591 and 1 TI 5679, and by a general research grant from the Ayerst Laboratories and Peter Bent Brigham Hospital.

Find articles by Taylor, W. in: JCI | PubMed | Google Scholar

Cardiovascular Unit and Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts

‡

Formerly, Postdoctoral Fellow, National Heart Institute.

Instructor in Surgery, Harvard Medical School and Associate in Surgery, Peter Bent Brigham Hospital.

Instructor in Medicine, Harvard Medical School and Junior Associate in Medicine, Peter Bent Brigham Hospital.

Assistant Professor of Medicine, Harvard Medical School; Physician, Peter Bent Brigham Hospital; and Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. Richard Gorlin, 721 Huntington Avenue, Boston, Mass., 02215.

Submitted for publication 20 October 1966; accepted 1 June 1967.

Reported in part at annual meeting, American Heart Association, Bal Harbour, Fla., October 1965 (1).

This work was supported by U. S. Public Health Service grants HE 08591 and 1 TI 5679, and by a general research grant from the Ayerst Laboratories and Peter Bent Brigham Hospital.

Find articles by Elliott, W. in: JCI | PubMed | Google Scholar

Cardiovascular Unit and Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts

‡

Formerly, Postdoctoral Fellow, National Heart Institute.

Instructor in Surgery, Harvard Medical School and Associate in Surgery, Peter Bent Brigham Hospital.

Instructor in Medicine, Harvard Medical School and Junior Associate in Medicine, Peter Bent Brigham Hospital.

Assistant Professor of Medicine, Harvard Medical School; Physician, Peter Bent Brigham Hospital; and Investigator, Howard Hughes Medical Institute.

Address requests for reprints to Dr. Richard Gorlin, 721 Huntington Avenue, Boston, Mass., 02215.

Submitted for publication 20 October 1966; accepted 1 June 1967.

Reported in part at annual meeting, American Heart Association, Bal Harbour, Fla., October 1965 (1).

This work was supported by U. S. Public Health Service grants HE 08591 and 1 TI 5679, and by a general research grant from the Ayerst Laboratories and Peter Bent Brigham Hospital.

Find articles by Gorlin, R. in: JCI | PubMed | Google Scholar

A method is described which measures the local effectiveness of the myocardial circulation, expressed as a clearance constant. Uniform clearance constants have been demonstrated in the normal canine and human myocardium. A distinct difference in clearance constants has been demonstrated between the normal canine myocardium and areas of naturally occurring disease. Heterogeneous clearance constants have been found in a majority of human subjects with coronary artery disease—the lowest rates being noted in areas of fibrous aneurysm.