Acid-Base Alterations and Renal Gluconeogenesis: Effect of pH, Bicarbonate Concentration, and P_CO2

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Abstract

In previous studies it was found that renal cortical slices from rats with induced metabolic acidosis have an increased capacity to produce glucose, whereas cortical slices from rats with metabolic alkalosis manifest decreased gluconeogenesis. To evaluate the relative influence of extracellular fluid pH, [HCO3-], and carbon dioxide tension on renal gluconeogenesis, we observed glucose production by cortex from rats with induced respiratory acidosis, and by cortex taken from normal animals and incubated in acid and alkaline media.

Authors

Donald E. Kamm, Robert E. Fuisz, A. David Goodman, George F. Cahill Jr.