Metabolism of Vitamin D₃-³H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine

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Abstract

Vitamin D3-3H has been administered intravenously to seven normal subjects, three patients with biliary fistulas, and four patients with cirrhosis. Plasma D3-3H half-times normally ranged from 20 to 30 hours. in vivo evidence that a metabolic transformation of vitamin D occurs was obtained, and a polar biologically active vitamin D metabolite was isolated from plasma.

Authors

Louis V. Avioli, Sook Won Lee, Joseph E. McDonald, Judith Lund, Hector F. DeLuca