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Research Article Free access | 10.1172/JCI105599

The Application of Starling's Law of Capillary Exchange to the Lungs

O. Robert Levine, Robert B. Mellins, Robert M. Senior, and Alfred P. Fishman

Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, N. Y.

Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, N. Y.

†

Recipient of a New York City Health Research Council Career Scientist Award, Contract I-259.

‡

Recipient of Career Development Award 1-K3-He-31,667-01 from the National Institutes of Health.

§

Research fellow of the U. S. Public Health Service.

ǁ

Address requests for reprints to Dr. Alfred P. Fishman, Dept. of Medicine, University of Chicago, Chicago, Ill. 60637.

*

Submitted for publication June 20, 1966; accepted February 17, 1967.

Supported by research grants HE-25741 and HE-08015 from the National Institutes of Health, U. S. Public Health Service, with additional support from the New York Heart Association and the Health Research Council of the City of New York, contract U-1613.

Presented at the May 1965 meeting of the Society for Pediatric Research, Philadelphia, Pa.

Find articles by Levine, O. in: PubMed | Google Scholar

Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, N. Y.

Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, N. Y.

†

Recipient of a New York City Health Research Council Career Scientist Award, Contract I-259.

‡

Recipient of Career Development Award 1-K3-He-31,667-01 from the National Institutes of Health.

§

Research fellow of the U. S. Public Health Service.

ǁ

Address requests for reprints to Dr. Alfred P. Fishman, Dept. of Medicine, University of Chicago, Chicago, Ill. 60637.

*

Submitted for publication June 20, 1966; accepted February 17, 1967.

Supported by research grants HE-25741 and HE-08015 from the National Institutes of Health, U. S. Public Health Service, with additional support from the New York Heart Association and the Health Research Council of the City of New York, contract U-1613.

Presented at the May 1965 meeting of the Society for Pediatric Research, Philadelphia, Pa.

Find articles by Mellins, R. in: PubMed | Google Scholar

Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, N. Y.

Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, N. Y.

†

Recipient of a New York City Health Research Council Career Scientist Award, Contract I-259.

‡

Recipient of Career Development Award 1-K3-He-31,667-01 from the National Institutes of Health.

§

Research fellow of the U. S. Public Health Service.

ǁ

Address requests for reprints to Dr. Alfred P. Fishman, Dept. of Medicine, University of Chicago, Chicago, Ill. 60637.

*

Submitted for publication June 20, 1966; accepted February 17, 1967.

Supported by research grants HE-25741 and HE-08015 from the National Institutes of Health, U. S. Public Health Service, with additional support from the New York Heart Association and the Health Research Council of the City of New York, contract U-1613.

Presented at the May 1965 meeting of the Society for Pediatric Research, Philadelphia, Pa.

Find articles by Senior, R. in: PubMed | Google Scholar

Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, N. Y.

Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, N. Y.

†

Recipient of a New York City Health Research Council Career Scientist Award, Contract I-259.

‡

Recipient of Career Development Award 1-K3-He-31,667-01 from the National Institutes of Health.

§

Research fellow of the U. S. Public Health Service.

ǁ

Address requests for reprints to Dr. Alfred P. Fishman, Dept. of Medicine, University of Chicago, Chicago, Ill. 60637.

*

Submitted for publication June 20, 1966; accepted February 17, 1967.

Supported by research grants HE-25741 and HE-08015 from the National Institutes of Health, U. S. Public Health Service, with additional support from the New York Heart Association and the Health Research Council of the City of New York, contract U-1613.

Presented at the May 1965 meeting of the Society for Pediatric Research, Philadelphia, Pa.

Find articles by Fishman, A. in: PubMed | Google Scholar

Published June 1, 1967 - More info

Published in Volume 46, Issue 6 on June 1, 1967
J Clin Invest. 1967;46(6):934–944. https://doi.org/10.1172/JCI105599.
© 1967 The American Society for Clinical Investigation
Published June 1, 1967 - Version history
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Abstract

The forces governing the movement of water across the pulmonary capillaries were studied in 39 intact, spontaneously breathing dogs. A situation favoring the net movement of water out of the pulmonary capillaries was created by means of partial pulmonary venous obstruction (left atrial balloon catheter) followed by rapid saline hemodilution. A predetermined difference between pulmonary capillary and plasma colloid osmotic pressures was maintained for periods of 1 to 2 hours. Left atrial (PLA) and plasma colloid osmotic pressures (πpl) were measured directly. The water content of the lungs was measured serially by an indicator-dilution technique, and at autopsy by drying the lungs. The rate of accumulation of lung water was measured in four groups of animals: in three of the groups, the capillary hydrostatic and colloid osmotic pressures were varied; in the fourth group, the right lymphatic duct was obstructed in addition.

The average rate of water accumulation in the lungs varied in a nonlinear way with the level of the capillary hydrostatic-plasma colloid osmotic pressure difference and was unaffected by the level of the capillary hydrostatic pressure. At low levels of PLA — πpl, water accumulated in the lung at an average rate of 0.09 g per g dry lung per hour per mm Hg pressure difference. At higher levels of PLA — πpl the average rate of accumulation was 0.22 g per g per hour per mm Hg ΔP; in most of the experiments in this group water accumulated in the lungs slowly during the first 30 minutes of the test period and more rapidly as the period was extended. Obstruction of right lymphatic duct outflow did not alter the rate of water accumulation. Based on the control data of the present experiments, the pericapillary pressure in normal lungs is estimated to be of the order of — 9 mm Hg in the normal dog lung. The filtration coefficient for the pulmonary capillaries is estimated to be of the order of one-tenth to one-twentieth of that for canine muscle capillaries. The data of the present study indicate that edema formation in lung tissue cannot be defined solely in terms of intravascular forces, but may be governed to a significant degree by changes in pericapillary forces in the pulmonary interstitium.

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