Citations to this article

The Effects of Chronic Hypoxemia on Electrolyte and Acid—Base Equilibrium: An Examination of Normocapneic Hypoxemia and of the Influence of Hypoxemia on the Adaptation to Chronic Hypercapnia
Daniel G. Sapir, … , David Z. Levine, William B. Schwartz
Daniel G. Sapir, … , David Z. Levine, William B. Schwartz
Published March 1, 1967
Citation Information: J Clin Invest. 1967;46(3):369-377. https://doi.org/10.1172/JCI105538.
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Research Article

The Effects of Chronic Hypoxemia on Electrolyte and Acid—Base Equilibrium: An Examination of Normocapneic Hypoxemia and of the Influence of Hypoxemia on the Adaptation to Chronic Hypercapnia

Abstract

We have carried out balance studies in normal dogs in order to appraise the effects of chronic hypoxemia on acid—base and electrolyte equilibrium. During the first phase of observation we produced a state of “pure” hypoxemia by reducing the oxygen concentration (utilizing nitrogen as a diluent) and by adding carbon dioxide to the environment in a concentration sufficient to keep arterial CO2 tension (PCO2) within normal limits. The data demonstrate that such a 9-day period of normocapneic hypoxemia has no effect on electrolyte excretion and is virtually without effect on plasma composition.

Authors

Daniel G. Sapir, David Z. Levine, William B. Schwartz

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Year: 2018 2014 2012 2006 2005 1991 1989 1983 1976 1975 1974 1972 1971 1970 1969 1968 Total
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Citation information

Citations to this article (19)

Title and authors Publication Year
Secondary Response to Chronic Respiratory Acidosis in Humans: A Prospective Study
SB González, G Menga, GA Raimondi, H Tighiouart, HJ Adrogué, NE Madias 		Kidney International Reports 2018
Comprehensive Physiology
SN Cheuvront, RW Kenefick 		Comprehensive Physiology 2014
Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice
SP DiBartola, HA de Morais 		Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice 2012
Disorders of Potassium: Hypokalemia and Hyperkalemia
SP DiBartola, HA de Morais 		Fluid Electrolyte and Acid-Base Disorders in Small Animal Practice 2006
Acid-Base Disorders and Their Treatment
L Hamm 		Acid-Base Disorders and Their Treatment 2005
Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis
RN Santella, DA Maddox, FJ Gennari 		Journal of Clinical Investigation 1991
Mechanisms of adaptation to chronic respiratory acidosis in the rabbit proximal tubule
R Krapf 		Journal of Clinical Investigation 1989
Acid-Base and Electrolyte Imbalance in Respiratory Failure
GL Ackerman, JA Arruda 		Medical Clinics of North America 1983
Abnormal renal function in the newborn infant
SS Daniel, LS James 		The Journal of Pediatrics 1976
Principles of Applied Clinical Chemistry Chemical Background and Medical Applications
S Natelson, EA Natelson 		1975
Carbon Dioxide and Metabolic Regulations
G Nahas, KE Schaefer 		1974
The nature of the renal adaptation to chronic hypocapnia
FJ Gennari, MB Goldstein, WB Schwartz 		Journal of Clinical Investigation 1972
Physiologic Consequences and Bodily Adaptations to Hyper- and Hypocapnia
A Rastegar, SO Thier 		Chest 1972
The Effect of Arterial Hypoxemia upon Acid-Base Parameters in Arterial Blood and Cisternal Gerebrospinal Fluid of the Rat
V MacMillan, BK Siesjö 		Acta Physiologica Scandinavica 1971
Respiratory-renal adjustments in chronic hypercapnia in man
RM Goldring, GM Turino, HO Heinemann 		The American Journal of Medicine 1971
Water, electrolytes and acid-base relationships in chronic cor pulmonale
GM Turino, RM Goldring, HO Heinemann 		Progress in Cardiovascular Diseases 1970
Computer evaluation of acid-base disorders
HL Bleich 		Journal of Clinical Investigation 1969
Acid-Base Response to Chronic Hypercapnia in Man
NC Brackett, CF Wingo, O Muren, JT Solano 		New England Journal of Medicine 1969
Renal Function during Prolonged Exposure to Hypoxia and Carbon Monoxide: II. Electrolyte Handling
HG Pauli, B Truniger, JK Larsen, RO Mulhausen 		Scandinavian Journal of Clinical & Laboratory Investigation 1968

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