The Production of Carbon Monoxide from Hemoglobin In Vivo

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Abstract

Dogs anesthetized with pentobarbital were shown to produce carbon monoxide at an average rate of 0.21 ± (SD) 0.05 ml per hour. After intravenous injection of erythrocytes damaged by incubation with N-ethylmaleimide, CO was produced in excess of base-line production for 3 to 4 hours with an average yield of 0.89 ± (SE) 0.046 μmole of carbon monoxide to 1 μmole of heme degraded.

Authors

R. F. Coburn, W. J. Williams, P. White, S. B. Kahn