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Citations to this article

Light and Heavy Chain Components of Gamma Globulins in Urines of Normal Persons and Patients with Agammaglobulinemia
John H. Vaughan, … , Ralph F. Jacox, Barry A. Gray
John H. Vaughan, … , Ralph F. Jacox, Barry A. Gray
Published February 1, 1967
Citation Information: J Clin Invest. 1967;46(2):266-279. https://doi.org/10.1172/JCI105529.
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Research Article

Light and Heavy Chain Components of Gamma Globulins in Urines of Normal Persons and Patients with Agammaglobulinemia

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Abstract

A heavy chain component of γG-globulins in normal urines has the characteristics of the proteolytic digestion product, Fc-fragment. This fragment is estimated to compose up to 15% of the gamma globulins present in urines. In contrast to urinary light chains, the urinary Fc-like fragment probably represents a catabolic component in normal γG-globulin metabolism.

Authors

John H. Vaughan, Ralph F. Jacox, Barry A. Gray

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Total citations by year

Year: 2011 2009 1999 1996 1995 1992 1991 1987 1984 1983 1980 1979 1978 1976 1974 1973 1972 1971 1970 1969 1968 1967 Total
Citations: 1 1 1 1 1 1 1 1 1 1 1 1 1 2 3 5 1 3 3 8 13 3 54
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (54)

Title and authors Publication Year
Advances in Clinical Chemistry
M Mahler
Advances in Clinical Chemistry Volume 54 2011
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Bence Jones-Proteine. Bence Jones Proteins
F Boege
LaboratoriumsMedizin 1999
Igg Subclasses in Capd Patients
RT Krediet, GC Koomen, A Vlug, DG Struijk, B Buis, RW Olden, AL Imholz
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1996
Species comparison of the content and composition of urinary proteins
GC Hard
Food and Chemical Toxicology 1995
The estimation of free light chains of immunoglobulins in biological fluids
CR Tillyer
International Journal of Clinical & Laboratory Research 1992
Gammopathy
J Jákó
1991
Metabolism of protein anticancer agents
V Bocci
Pharmacology & Therapeutics 1987
Characterization of glomerular permeabilty and proteinuria in acute hypertension in the rat
G Olivetti, K Kithier, F Giacomelli, J Wiener
Kidney International 1984
Gibt es die ?Febrile Proteinurie??
WH Boesken, A Mamier, H Neumann, R Engelhardt
Klinische Wochenschrift 1983
Light chain polymerism in normal individuals, in patients with severe proteinuria and in normals with inhibited tubular protein reabsorption by lysine
K SøLling
Scandinavian Journal of Clinical & Laboratory Investigation 1980
Six related protein products from a single patient with multiple myeloma
R Jemmerson, B Kaplan, MD Denton, P Anderas, B Anderson, E Margoliash
Biochemistry 1979
Free light chain synthesis by neoplastic cells in chronic lymphocytic leukaemia and non-Hodgkin's lymphoma
J Gordon, AR Howlett, JL Smith
Immunology 1978
Bence-Jones Proteins and Light Chains of Immunoglobulins
A Solomon
New England Journal of Medicine 1976
A Study on the Urinary Low Molecular Proteins
M Mori
1976
PROTEINURIA IN NON-RENAL INFECTIOUS DISEASES
H Jensen, K Henriksen
Acta Medica Scandinavica 1974
Heavy chain disease, rheumatoid arthritis and cryoglobulinemia
RR Kretschmer, J Pizzuto, JG Ll, M López
Clinical Immunology and Immunopathology 1974
Structure and Function of Plasma Proteins
AC Allison
1974
Low-Molecular-Weight Antibody in Rabbit Urine: Identity with the Fab Immunoglobulin Fragment
JC Jensenius
Scandinavian Journal of Immunology 1973
Detection in Normal Plasma of Immunoglobulin resembling the Protein of γ-Chain Disease
CW Lam, GT Stevenson
Nature 1973
Urinary immunoglobulins in the adult pig
FJ Bourne, J Curtis, LS Wah
Immunology 1973
The binding of haptens by the polypeptide chains of rabbit antibody molecules
GT Stevenson
Biochemical Journal 1973
The occurrence of immunoglobulin fragments, two types of lactoferrin and a lactoferrin-IgG2 complex in bovine colostral and milk whey
JE Butler
Biochimica et Biophysica Acta (BBA) - Protein Structure 1973
Polymer formation during the degradation of human light chain and Bence-Jones proteins by an extract of the lysosomal fraction of normal human kidney
M Tan, W Epstein
Immunochemistry 1972
Immunologische Untersuchungen zur Proteinurie nierentransplantierter Patienten
G Hermann, V Zühlke
Zeitschrift für Die Gesamte Experimentelle Medizin einschließlich experimentelle Chirurgie 1971
Immunoglobulins of normal human urine and urethral secretions
DW Burdon
Immunology 1971
Urinary Immunoglobulin Components in Normal, Tubular, and Glomerular Proteinuria: Quantities and Characteristics of Free Light Chains, IgG, IgA, and Fcγ Fragment
PA Peterson, I Berggård
European Journal of Clinical Investigation 1971
Urinary Immunoglobulins in Patients With Cancer
FD Lindström, RC Williams, A Theologides
Scandinavian Journal of Haematology 1970
Quantitative studies on urinary immunoglobulins in hospital patients, including patients with urinary tract infection
DW Burdof
Clinical & Experimental Immunology 1970
Further studies on thermosoluble proteins in serum and urine
JR Poortmans
Clinica Chimica Acta 1970
Immunologische Untersuchungen zur Proteinurie gesunder Personen mit Nachweis von Nierenproteinen
V Zühlke, G Hermann
Zeitschrift für Die Gesamte Experimentelle Medizin einschließlich experimentelle Chirurgie 1969
Urinary Excretion of a γM-related Substance following Muscular Exercise
JR Poortmans
Nature 1969
Characterization of the Fc′ Fragment of Immunoglobulin G in Normal Human Urine
MW Turner, I Berggård
Nature 1969
Urinary light chain excretion in leukaemia and lymphoma
FD Lindström, RC Williams, A Theologides
Clinical & Experimental Immunology 1969
Élimination urinaire de molécules différentes des chaînes légères au cours des dysglobulinémies ”monoclonales”
JM Fine
Revue Française de Transfusion 1969
A study of the relation of seronegative and seropositive rheumatoid arthritis to each other and to necrotizing vasculitis
ES Mongan, RM Cass, RF Jacox, JH Vaughan
The American Journal of Medicine 1969
Protides of the Biological Fluids
PA Small, RH Waldman
Protides of the Biological Fluids 1969
Polymeric Forms of Free Normal κ and λ Chains of Human Immunoglobulin
I Berggard, PA Peterson
The Journal of biological chemistry 1969
Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise
J Poortmans, RW Jeanloz
Journal of Clinical Investigation 1968
Secretory γA in normal urine
J Bienenstock, TB Tomasi
Journal of Clinical Investigation 1968
Local immune response in experimental pyelonephritis
JD Lehmann, JW Smith, TE Miller, JA Barnett, JP Sanford
Journal of Clinical Investigation 1968
Serum and urine light chain levels in benign monoclonal gammapathies, multiple myeloma and Waldenström's macroglobulinaemia
F Dammacco, J Waldenström
Clinical & Experimental Immunology 1968
Immunofluorescent studies of the myeloma kidney with special reference to light chain disease
DF Levi, RC Williams, FD Lindstrom
The American Journal of Medicine 1968
Some chemical and biological properties of the F′c fragment of human γG globulins
S Irimajiri, EC Franklin, B Frangione
Immunochemistry 1968
Les protéinuries des immunoglobulinopathies
JP Lebreton, C Rivat, L Rivat, C Ropartz
Revue Française de Transfusion 1968
Thymic alymphoplasia associated with the hemolytic-uremic syndrome
LD Dubilier, JA Chadwick, JP Leddy
The Journal of Pediatrics 1968
Immunoglobulin levels in sudden unexpected deaths of infants
PC Balduzzi, JH Vaughan, RM Greendyke
The Journal of Pediatrics 1968
A Unique lymphoproliferative disorder associated with an IgM platelet agglutinin, diffuse hypergammaglobulinemia, amyloid deposition and excessive urinary excretion of IgG fragments
RW Colman, CK Osterland, RF Dorfman, H Chaplin
The American Journal of Medicine 1968
Heavy-Chain Disease: Report of a Seventh Case
LL Ellman, KJ Bloch
New England Journal of Medicine 1968
Defective (incomplete) synthesis of immunoglobulin heavy polypeptide chains as the cause of a myeloma-like disease
J Śnigurowicz, K Murawski, M Kraj, W Jóźwiak, B Żupańska
Clinica Chimica Acta 1968
Relation of intracytoplasmic inclusions in joint fluid leukocytes to anti-γG globulins
JH Vaughan, RF Jacox, P Noell
Arthritis & Rheumatism 1968
The distribution of serum immunoglobulins, anti-γ-G globulins (“rheumatoid factors”) and antinuclear antibodies in white and negro subjects in Evans County, Georgia
MA Lichtman, JH Vaughan, CG Hames
Arthritis & Rheumatism 1967
Effect of impaired hepatic and renal function on [131]bence jones protein catabolism in human subjects
TA Miettinen, M Kekki
Clinica Chimica Acta 1967
Paraproteins and bence jones protein
EN Wardle
British medical journal 1967

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