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Research Article Free access | 10.1172/JCI105518

Glucose Titration Studies in Patients with Chronic Progressive Renal Disease

Richard E. Rieselbach, Steward W. Shankel, Eduardo Slatopolsky, Herbert Lubowitz, and Neal S. Bricker

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

†

Special Fellow, U. S. Public Health Service. Present address: Dept. of Medicine, University of Wisconsin, School of Medicine, Madison, Wisc.

‡

Research Fellow, U. S. Public Health Service.

§

Research Career Award, U. S. Public Health Service.

Address requests for reprints to Dr. Neal S. Bricker, Barnes and Wohl Hospitals, 660 S. Euclid Ave., St. Louis, Mo. 63110.

*

Submitted for publication June 27, 1966; accepted October 20, 1966.

Supported by U. S. Public Health research grant AM-09976, training grant AM-5248, and grant FR-36 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources.

Find articles by Rieselbach, R. in: JCI | PubMed | Google Scholar

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

†

Special Fellow, U. S. Public Health Service. Present address: Dept. of Medicine, University of Wisconsin, School of Medicine, Madison, Wisc.

‡

Research Fellow, U. S. Public Health Service.

§

Research Career Award, U. S. Public Health Service.

Address requests for reprints to Dr. Neal S. Bricker, Barnes and Wohl Hospitals, 660 S. Euclid Ave., St. Louis, Mo. 63110.

*

Submitted for publication June 27, 1966; accepted October 20, 1966.

Supported by U. S. Public Health research grant AM-09976, training grant AM-5248, and grant FR-36 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources.

Find articles by Shankel, S. in: JCI | PubMed | Google Scholar

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

†

Special Fellow, U. S. Public Health Service. Present address: Dept. of Medicine, University of Wisconsin, School of Medicine, Madison, Wisc.

‡

Research Fellow, U. S. Public Health Service.

§

Research Career Award, U. S. Public Health Service.

Address requests for reprints to Dr. Neal S. Bricker, Barnes and Wohl Hospitals, 660 S. Euclid Ave., St. Louis, Mo. 63110.

*

Submitted for publication June 27, 1966; accepted October 20, 1966.

Supported by U. S. Public Health research grant AM-09976, training grant AM-5248, and grant FR-36 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources.

Find articles by Slatopolsky, E. in: JCI | PubMed | Google Scholar

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

†

Special Fellow, U. S. Public Health Service. Present address: Dept. of Medicine, University of Wisconsin, School of Medicine, Madison, Wisc.

‡

Research Fellow, U. S. Public Health Service.

§

Research Career Award, U. S. Public Health Service.

Address requests for reprints to Dr. Neal S. Bricker, Barnes and Wohl Hospitals, 660 S. Euclid Ave., St. Louis, Mo. 63110.

*

Submitted for publication June 27, 1966; accepted October 20, 1966.

Supported by U. S. Public Health research grant AM-09976, training grant AM-5248, and grant FR-36 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources.

Find articles by Lubowitz, H. in: JCI | PubMed | Google Scholar

Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.

†

Special Fellow, U. S. Public Health Service. Present address: Dept. of Medicine, University of Wisconsin, School of Medicine, Madison, Wisc.

‡

Research Fellow, U. S. Public Health Service.

§

Research Career Award, U. S. Public Health Service.

Address requests for reprints to Dr. Neal S. Bricker, Barnes and Wohl Hospitals, 660 S. Euclid Ave., St. Louis, Mo. 63110.

*

Submitted for publication June 27, 1966; accepted October 20, 1966.

Supported by U. S. Public Health research grant AM-09976, training grant AM-5248, and grant FR-36 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources.

Find articles by Bricker, N. in: JCI | PubMed | Google Scholar

Published February 1, 1967 - More info

Published in Volume 46, Issue 2 on February 1, 1967
J Clin Invest. 1967;46(2):157–163. https://doi.org/10.1172/JCI105518.
© 1967 The American Society for Clinical Investigation
Published February 1, 1967 - Version history
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Abstract

Glucose titration studies were performed on 17 patients with either chronic pyelonephritis or chronic glomerulonephritis. Glomerular filtration rates for the group ranged from 4.3 to 58.1 ml per minute. In none of the patients in whom the glomerular filtration rate was over 15 ml per minute was there appreciable splay, and the mean titration curve for these patients resembled that obtained by Smith and associates in normal man (1). In half of this group of eight patients, GFR ranged from 16.6 to 22.7 ml per minute; in the other half values ranged from 42.3 to 58.1 ml per minute. Yet, the mean titration curves were identical for the two groups. In addition, no difference was observed in the titration curves for patients with pyelonephritis and those with glomerulonephritis. In patients with GFR values below 15 ml per minute, increased splay was observed, and below a GFR of 10 ml per minute, the splay was very marked. Both the absence of exaggerated splay in patients with reduction of glomerular filtration rate by as much as 85%, and the emergence of exaggerated splay in patients with more marked reduction of GFR, require explanation. Theoretical considerations are presented in the text.

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