1) Measured during spontaneous breathing in ten patients with diffuse interstitial lung disease, total pulmonary resistance averaged 3.53 ± 1.56 cm H2O per L per second; airway resistance, 1.63 ± 0.79 cm H2O per L per second; and lung tissue resistance, 1.90 ± 0.95 cm H2O per L per second (range, 0.89 to 3.96). The lung tissue resistance was on an average about four times higher in patients with lung fibrosis than in ten healthy persons of the same age. No significant difference in airway resistance was found between healthy subjects and patients.
