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Citations to this article

Bromocriptine restores tolerance in estrogen-treated mice
Elena Peeva, … , Linda Spatz, Betty Diamond
Elena Peeva, … , Linda Spatz, Betty Diamond
Published December 1, 2000
Citation Information: J Clin Invest. 2000;106(11):1373-1379. https://doi.org/10.1172/JCI10420.
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Article

Bromocriptine restores tolerance in estrogen-treated mice

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Abstract

Estrogen can modulate autoimmunity in certain models of systemic lupus erythematosus. Recently, we have shown that it can mediate survival and activation of anti-DNA B cells in a mouse transgenic for the heavy chain of a pathogenic anti-DNA antibody. To identify whether estrogen effects reflect increased prolactin secretion, we characterized B-cell autoreactivity in transgenic mice given both bromocriptine (an inhibitor of prolactin secretion) and estradiol. Treatment of mice with estradiol plus bromocriptine led to reduced titers of anti-DNA antibodies and diminished IgG deposition in kidneys compared with treatment with estradiol alone. However, mice treated with estradiol plus bromocriptine showed an expansion of transgene-expressing B cells and enhanced Bcl-2 expression, similar to those of estradiol-treated mice. We identified anergic high-affinity anti-DNA B cells in mice treated with estradiol plus bromocriptine, and we showed by molecular analysis of anti-DNA hybridomas that their B cells derive from a naive repertoire. Thus, the estradiol-induced breakdown in B-cell tolerance can be abrogated by bromocriptine, which induces anergy in the high-affinity DNA-reactive B cells. These studies demonstrate that some of the effects of estrogen on naive autoreactive B cells require the presence of prolactin and, thus, suggest potential therapeutic interventions in lupus.

Authors

Elena Peeva, Christine Grimaldi, Linda Spatz, Betty Diamond

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Total citations by year

Year: 2024 2023 2018 2017 2015 2014 2013 2011 2010 2009 2007 2004 2003 2002 Total
Citations: 1 1 1 1 1 1 1 1 2 3 2 1 3 1 20
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Citations to this article (20)

Title and authors Publication Year
Hormones and B-cell development in health and autoimmunity
Santana-Sánchez P, Vaquero-García R, Legorreta-Haquet MV, Chávez-Sánchez L, Chávez-Rueda AK
Frontiers in immunology 2024
Abnormally high expression of D1-like dopamine receptors on lupus CD4+ T cells promotes Tfh cell differentiation
Wu F, Xiang Z, He Z, Yi P, Yang M, Wu H, Hu M
Lupus Science & Medicine 2023
Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis
R Xue, H Zhang, J Pan, Z Du, W Zhou, Z Zhang, Z Tian, R Zhou, L Bai
Frontiers in immunology 2018
Prolactin has a pathogenic role in systemic lupus erythematosus
LJ Jara, G Medina, MA Saavedra, O Vera-Lastra, H Torres-Aguilar, C Navarro, MV Mercado, LR Espinoza
Immunologic Research 2017
The Effects of Bromocriptine on Preventing Postpartum Flare in Systemic Lupus Erythematosus Patients from South China
Q Qian, L Liuqin, L Hao, Y Shiwen, Z Zhongping, C Dongying, L Fan, X Hanshi, Y Xiuyan, Y Yujin
Journal of Immunology Research 2015
The Dopaminergic System in Autoimmune Diseases
R Pacheco, F Contreras, M Zouali
Frontiers in immunology 2014
Prolactin rescues and primes autoreactive B cells directly and indirectly through dendritic cells in B6.Sle3 mice
J Gonzalez, S Saha, E Peeva
Clinical & Experimental Immunology 2013
Prolactin and Autoimmunity: Hyperprolactinemia Correlates with Serositis and Anemia in SLE Patients
H Orbach, G Zandman-Goddard, M Boaz, N Agmon-Levin, H Amital, Z Szekanecz, G Szucs, J Rovensky, E Kiss, A Doria, A Ghirardello, J Gomez-Arbesu, L Stojanovich, F Ingegnoli, PL Meroni, B Rozman, M Blank, Y Shoenfeld
Clinical Reviews in Allergy & Immunology 2011
PD-1, gender, and autoimmunity
RK Dinesh, BH Hahn, RP Singh
Autoimmunity Reviews 2010
The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies
CE Weckerle, TB Niewold
Clinical Reviews in Allergy & Immunology 2010
The Multi-faceted Influences of Estrogen on Lymphocytes: Toward Novel Immuno-interventions Strategies for Autoimmunity Management
E Karpuzoglu, M Zouali
Clinical Reviews in Allergy & Immunology 2009
Prolactin alters the mechanisms of B cell tolerance induction
S Saha, J Gonzalez, G Rosenfeld, H Keiser, E Peeva
Arthritis & Rheumatism 2009
Prolactin, Systemic Lupus Erythematosus, and Autoreactive B Cells: Lessons Learnt from Murine Models
S Saha, A Tieng, KP Pepeljugoski, G Zandamn-Goddard, E Peeva
Clinical Reviews in Allergy & Immunology 2009
Aging and estrogen: modulation of inflammatory responses after injury
CR Gomez, TP Plackett, EJ Kovacs
Experimental Gerontology 2007
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice
F Wang, SM Roberts, EJ Butfiloski, ES Sobel
International Immunopharmacology 2007
Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene
GJ Shim, LL Kis, M Warner, JA Gustafsson
Proceedings of the National Academy of Sciences 2004
Prolactin modulates the naive B cell repertoire
Elena Peeva, Daniel Michael, James Cleary, Jeffrey Rice, Xian Chen, Betty Diamond
Journal of Clinical Investigation 2003
Effects of Prolactin on Cloned Human T-Lymphocytes
Z Dogusan, N Martens, P Stinissen, N Hellings, N Demotte, R Hooghe, EL Hooghe-Peters
Endocrine 2003
Pathogenesis of systemic lupus erythematosus
Mok CC, Lau CS
Journal of clinical pathology 2003
Estrogen alters thresholds for B cell apoptosis and activation
Christine M. Grimaldi, James Cleary, A. Selma Dagtas, Dariush Moussai, Betty Diamond
Journal of Clinical Investigation 2002

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