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Citations to this article

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
Tanya Ponomaryov, … , Dov Zipori, Tsvee Lapidot
Tanya Ponomaryov, … , Dov Zipori, Tsvee Lapidot
Published December 1, 2000
Citation Information: J Clin Invest. 2000;106(11):1331-1339. https://doi.org/10.1172/JCI10329.
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Article Article has an altmetric score of 7

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

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Abstract

The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damaging agents (ionizing irradiation, cyclophosphamide, and 5-fluorouracil) caused an increase in SDF-1 expression and in CXCR4-dependent homing and repopulation by human stem cells transplanted into NOD/SCID mice. Our findings suggest that immature osteoblasts and endothelial cells control stem cell homing, retention, and repopulation by secreting SDF-1, which also participates in host defense responses to DNA damage.

Authors

Tanya Ponomaryov, Amnon Peled, Isabelle Petit, Russell S. Taichman, Liliana Habler, Judith Sandbank, Fernando Arenzana-Seisdedos, Aude Magerus, Antonio Caruz, Nobutaka Fujii, Arnon Nagler, Meir Lahav, Martin Szyper-Kravitz, Dov Zipori, Tsvee Lapidot

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Total
Citations: 4 2 4 6 9 8 6 8 6 14 14 14 16 19 9 20 14 8 7 6 3 4 2 203
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Citations to this article in year 2020 (9)

Title and authors Publication Year
Tumor Microenvironment: The Main Driver of Metabolic Adaptation
J Serpa
2020
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
J Zarrer, MT Haider, DJ Smit, H Taipaleenmäki
Biomolecules 2020
Hematopoiesis and Cardiovascular Disease
WC Poller, M Nahrendorf, FK Swirski
Circulation research 2020
Analysis of a large single institution cohort of related donors fails to detect a relation between SDF1/CXCR4 or VCAM/VLA4 genetic polymorphisms and the level of hematopoietic progenitor cell mobilization in response to G-CSF
S Garciaz, P Sfumato, A Granata, AM Imbert, C Fournel, B Calmels, C Lemarie, J Chiaroni, D Blaise, JM Boher, C Picard, C Chabannon, J di Cristofaro, H Bönig
PloS one 2020
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis
P Scharf, MF Broering, GH da Rocha, SH Farsky
International journal of molecular sciences 2020
Tumour Dissemination in Multiple Myeloma Disease Progression and Relapse: A Potential Therapeutic Target in High-Risk Myeloma
MN Zeissig, AC Zannettino, K Vandyke
Cancers 2020
At the Bench: Pre‐clinical evidence for multiple functions of CXCR4 in cancer
GD Luker, J Yang, A Richmond, S Scala, C Festuccia, M Schottelius, HJ Wester, J Zimmermann
Journal of leukocyte biology 2020
Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration
OC Olson, YA Kang, E Passegué
Cold Spring Harbor Perspectives in Medicine 2020
Phase I clinical trial of intra‐bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation
T Goto, M Murata, T Nishida, S Terakura, S Kamoshita, Y Ishikawa, Y Ushijima, Y Adachi, S Suzuki, K Kato, A Hirakawa, S Nishiwaki, N Nishio, Y Takahashi, Y Kodera, T Matsushita, H Kiyoi
Stem Cells Translational Medicine 2020

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Referenced in 11 patents
Mentioned by 1 peer review sites
174 readers on Mendeley
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