Diabetic patients are more than twice as likely to die from a heart attack as non-diabetic patients, but the mechanisms that underlie increased heart attack-related mortality in diabetic...
Published February 15, 2013

Blood coagulation is a host defense system that prevents the spread of pathogens. It is mediated by a variety of proteases (protein-cleaving enzymes) that also activate cells by cleaving a...
Published February 8, 2013

T cells that recognize the "self", known as autoreactive T cells, can infiltrate the central nervous system (CNS) and cause disorders like multiple sclerosis. Using a rat model of multiple...
Published February 1, 2013

Sepsis is an illness in which the body has a severe reaction to a bacterial infection. Bacterial toxins activate the immune system, causing widespread inflammation and increased blood calcium...
Published January 25, 2013

Prostate cancer is one of the most common malignancies in men. It is highly treatable in early stages; however, once the cancer becomes metastatic, it is extremely difficult to cure.  Yoshioka...
Published January 25, 2013

Bone is a dynamic organ that undergoes continuous remodeling through the action of osteoblasts that create new bone and osteoclasts that resorb old bone. To identify factors that control the...
Published January 16, 2013

SPARC (secreted protein acidic and rich in cysteine) is an extracellular matrix glycoprotein that has been implicated in multiple aspects of human cancer. In bladder cancer, it has been...
Published January 16, 2013

Mutations in the human cathepsin K (CTSK) cause pycnodysostosis, an autosomal recessive disease characterized by short stature and elevated bone density (osteopetrosis). In mice, global...
Published January 16, 2013

Patients with chronic kidney disease (CKD)  frequently suffer from vascular calcification that can cause chronic heart failure. Similar to patients with CKD, mice that lack the FGF23 receptor...
Published January 9, 2013

Tuberculosis (TB) is one the most prevalent infectious diseases in the world, but only 10% of infected individuals develop active TB.  One of the most important challenges in TB control is to be...
Published January 2, 2013