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Immune inhibitor receptor LAIR1 in gliomas and fibroblast–secreted collagen
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand...
Published February 15, 2024
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Pulmonary artery endothelial function and hypertension are impacted by RAB7 deficiency
In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7...
Published February 1, 2024
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Microglial activation and tau transmission aggravated by Galectin-3 in tauopathy
In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation...
Published January 16, 2024
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Numerous shared tumor antigens in breast cancer immunopeptidomes
In this episode, Eralda Kina and Claude Perreault explain how using proteogenomics, their manuscript identifies tumor-specific antigens in primary human breast cancers...
Published January 2, 2024
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Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2
In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression...
Published December 15, 2023
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Predicting diabetic kidney disease and mediating kidney injury in patients with endogenous adenine
In this episode, Kumar Sharma explains that urine adenine/creatinine is a marker for kidney failure in patients with diabetes, and endogenous adenine plays a potential causative role in diabetic kidney disease...
Published November 2, 2023
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A link between serotonin and proliferation is revealed in Cronkhite-Canada syndrome patients
In this episode, Sarah Blutt explains how this work demonstrates the power of organoids to understand and develop new therapies for diseases...
Published November 1, 2023
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A model of inherited retinal channelopathy with a nonviral base editing of KCNJ13 mutation
In this episode, Bikash Pattnaik and colleagues explain that their study encompasses the application of genomic medicine to treat monoigenic retinal degeneratiion using base editing genen therapy delivered delivered through novel nonviral platform...
Published October 5, 2023
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Cerebrospinal fluid quinolinic acid and delirium and mortality in hip-fracture patients
In this episode, Lasse Giil explains that activation of the kynurenine pathway in delirium leads to high brain concentrations the endogenous neurotoxin quinolinic acid...
Published January 20, 2023
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BMX controls in cancer
In this episode, Nima Sharifi and Xiuxiu Li discuss how the BMX kinase regulates androgen and estrogen biosynthesis and is a drug target for sex steroid dependent cancers...
Published January 17, 2023
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