In this episode, Editor at Large Ushma Neill interviews Dr. Zhijian (James) Chen. Zhijian (James) Chen (University of Texas Southwestern and HHMI) has had a storied research career focused on the molecular mechanisms of innate immunity, the body's immediate response to pathogens. His discovery of the cGAS enzyme that senses foreign and self-DNA brought him to New York to accept the 2024 Albert Lasker Basic Medical Research Award for a recent conversation.