We shift our format this month to bring you three giants in medicine, Dr. Jesse Roth of the Feinstein Institutes for Medical Research, Dr. C. Ronald Kahn of the Joslin Diabetes Center at Harvard Medical School, and Dr. Jeffrey Flier of Harvard Medical School, as part of the JCI’s salute to the 100th anniversary of the discovery of insulin. Roth, Kahn, and Flier all played instrumental roles in the discovery and description of the insulin receptor and in elucidating the critical role it plays in diabetes. Enjoy the full interview with their anecdotes and to get a glimpse of their extraordinary camaraderie.