After a 20-year focus on the water channel aquaporin (work for which he shared the 2003 Nobel Prize in Chemistry), Peter Agre has turned his attention to malaria. He currently serves as Director of the Johns Hopkins Malaria Research Institute. In this interview, Agre displays his witty sense of humor, including vignettes related to running for Senate, dancing to the Buena Vista Social Club, and his desire to be known as the Victor Borge of science.