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Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?
Nenad Bursac
Nenad Bursac
Published June 17, 2014
Citation Information: J Clin Invest. 2014;124(7):2850-2853. https://doi.org/10.1172/JCI76628.
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Commentary

Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

Abstract

Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.

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Nenad Bursac

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