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A VISTA on PD-1H
Yang Liu
Yang Liu
Published April 17, 2014
Citation Information: J Clin Invest. 2014;124(5):1891-1893. https://doi.org/10.1172/JCI75798.
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Commentary

A VISTA on PD-1H

Abstract

Three years ago, two research groups independently identified a previously undescribed T cell cosignaling molecule; one referred to it as V-domain Ig suppressor of T cell activation (VISTA), and the other used the term programmed death-1 homolog (PD-1H). Recombinant and ectopically expressed PD-1H functions as a coinhibitory ligand for T cell responses. However, the function of endogenous PD-1H is not clear. In this issue of the JCI, Flies and colleagues demonstrate that endogenous PD-1H on both T cells and APCs serves as a coinhibitory molecule for T cell activation and provide further support for targeting PD-1H as a therapeutic strategy for transplantation and cancers.

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Yang Liu

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