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Desmoglein-1, differentiation, and disease
Christoph M. Hammers, John R. Stanley
Christoph M. Hammers, John R. Stanley
Published March 25, 2013
Citation Information: J Clin Invest. 2013;123(4):1419-1422. https://doi.org/10.1172/JCI69071.
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Commentary

Desmoglein-1, differentiation, and disease

Abstract

Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al. elucidate how the binding of the DSG1 cytoplasmic tail to the scaffolding protein Erbin decreases signaling through the Ras-Raf pathway to promote stratification and differentiation of keratinocytes in the epidermis.

Authors

Christoph M. Hammers, John R. Stanley

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