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DAMPs ramp up drug toxicity
Jacquelyn J. Maher
Jacquelyn J. Maher
Published January 26, 2009
Citation Information: J Clin Invest. 2009;119(2):246-249. https://doi.org/10.1172/JCI38178.
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Commentary

DAMPs ramp up drug toxicity

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Abstract

The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and colleagues report that DNA released from dying hepatocytes is a key stimulus of innate immune activation in the acetaminophen-treated mouse liver (see the related article beginning on page 305). They present evidence indicating that hepatocyte DNA promotes immune activation by acting as a danger-associated molecular pattern (DAMP) that stimulates cytokine production in neighboring sinusoidal endothelial cells via Tlr9 and the Nalp3 inflammasome.

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Jacquelyn J. Maher

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