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Poliovirus proves IRES-istible in vivo
Bert L. Semler
Bert L. Semler
Published June 15, 2004
Citation Information: J Clin Invest. 2004;113(12):1678-1681. https://doi.org/10.1172/JCI22139.
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Commentary

Poliovirus proves IRES-istible in vivo

Abstract

The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5′ noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at the level of translation. A report in this issue of the JCI reveals that poliovirus tropism is, in part, determined after internal ribosome entry.

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Bert L. Semler

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