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Hepatoprotection via the IL-6/Stat3 pathway
Rebecca Taub
Rebecca Taub
Published October 1, 2003
Citation Information: J Clin Invest. 2003;112(7):978-980. https://doi.org/10.1172/JCI19974.
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Commentary

Hepatoprotection via the IL-6/Stat3 pathway

Abstract

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.

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Rebecca Taub

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