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Salicylic acid: an old dog, new tricks, and staphylococcal disease
Mathias Herrmann
Mathias Herrmann
Published July 15, 2003
Citation Information: J Clin Invest. 2003;112(2):149-151. https://doi.org/10.1172/JCI19143.
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Commentary

Salicylic acid: an old dog, new tricks, and staphylococcal disease

Abstract

Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus–associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and α-hemolysin — virulence factors necessary for bacterial replication in host tissues and, now, potential therapeutic targets.

Authors

Mathias Herrmann

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