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AIP1: a new player in TNF signaling
M. Eugenia Guicciardi, Gregory J. Gores
M. Eugenia Guicciardi, Gregory J. Gores
Published June 15, 2003
Citation Information: J Clin Invest. 2003;111(12):1813-1815. https://doi.org/10.1172/JCI18911.
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Commentary

AIP1: a new player in TNF signaling

Abstract

Apoptosis signal–regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting protein, AIP1, plays an important role in TNF-α–induced ASK1 activation by facilitating dissociation from its inhibitor.

Authors

M. Eugenia Guicciardi, Gregory J. Gores

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