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A protective role for microRNA-688 in acute kidney injury
Nicholas Chun, … , Steven G. Coca, John Cijiang He
Nicholas Chun, … , Steven G. Coca, John Cijiang He
Published November 12, 2018
Citation Information: J Clin Invest. 2018;128(12):5216-5218. https://doi.org/10.1172/JCI124923.
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Commentary

A protective role for microRNA-688 in acute kidney injury

Abstract

Ischemia-reperfusion (I/R) sets off a devastating cascade of events, leading to cell death and possible organ failure. Treatments to limit I/R-associated damage are lacking, and the pathways that drive injury are poorly understood. In this issue of the JCI, Wei and colleagues identify microRNA-668 (miR-668) as a protective factor in acute kidney injury (AKI). miR-668 was shown to repress mitochondrial fission–associated protein MTP18, thereby inhibiting pathogenic mitochondrial fragmentation. In murine models of I/R-induced AKI, treatment with a miR-668 mimetic reduced mitochondrial fragmentation and improved renal function. Moreover, HIF-1α was shown to be required for miR-688 expression in response to I/R. Importantly, Wei et al. show miR-668 upregulation in a cohort of human patients with AKI. Together, these results identify a HIF-1α/miR-668/MTP18 axis that may have potential as a therapeutic target for AKI.

Authors

Nicholas Chun, Steven G. Coca, John Cijiang He

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