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Platelets mediate neutrophil-dependent immune complex nephritis in the rat.
R J Johnson, … , C Pruchno, W G Couser
R J Johnson, … , C Pruchno, W G Couser
Published October 1, 1988
Citation Information: J Clin Invest. 1988;82(4):1225-1235. https://doi.org/10.1172/JCI113720.
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Research Article

Platelets mediate neutrophil-dependent immune complex nephritis in the rat.

Abstract

Neutrophils and platelets are frequently present in glomeruli in immune glomerulonephritis (GN). No role for the platelet in acute neutrophil-mediated renal injury has been defined. We investigated a neutrophil-mediated model of subendothelial immune complex GN in the rat. Rats were platelet-depleted (mean platelet less than 10,000/microliter) with goat anti-platelet IgG before induction of GN by the renal artery perfusion of concanavalin A followed by anti-concanavalin A IgG. Platelet-depletion resulted in a significant reduction in albuminuria (7 +/- 2 vs. 55 +/- 10 mg/24 h) and fractional albumin excretion (0.045 +/- 0.01 vs. 0.410 +/- 0.09) compared with controls. The decrease in albuminuria was not due to differences in blood or glomerular neutrophil counts, complement, renal function, or glomerular antibody binding. Platelet-depleted rats had equivalent subendothelial deposits and glomerular endothelial cell injury but had minimal platelet infiltrates and fibrin deposition compared with controls. These studies demonstrate a role for platelets in mediating acute neutrophil-induced glomerular injury and proteinuria in this model of GN.

Authors

R J Johnson, C E Alpers, P Pritzl, M Schulze, P Baker, C Pruchno, W G Couser

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