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Citation Information: J Clin Invest. 1982;70(5):1066-1073. https://doi.org/10.1172/JCI110694.
Abstract
Human skin fibroblasts synthesize and accumulate glycosaminoglycans (GAG). Recently, we reported that fibroblasts incubated in thyroid hormone-deficient media accumulate more GAG than do cultures incubated in the same media enriched with 0.1 μM triiodothyronine (T3) (1981. Endocrinology. 108: 2397). The current study characterizes that enhanced accumulation. Confluent cultures were maintained in thyroid hormone-deficient media without or with added T3, labeled with [3H]acetate and analyzed for total [3H]GAG and [3H]hyaluronic acid content.
Authors
Terry J. Smith, Yoshiharu Murata, Allen L. Horwitz, Louis Philipson, Samuel Refetoff
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