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Mechanisms of K+ Transport in Isolated Turtle Urinary Bladder: INDUCTION OF ACTIVE K+ SECRETION IN A K+-ABSORBING EPITHELIUM
Russell F. Husted, Philip R. Steinmetz
Russell F. Husted, Philip R. Steinmetz
Published October 1, 1982
Citation Information: J Clin Invest. 1982;70(4):832-834. https://doi.org/10.1172/JCI110679.
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Mechanisms of K+ Transport in Isolated Turtle Urinary Bladder: INDUCTION OF ACTIVE K+ SECRETION IN A K+-ABSORBING EPITHELIUM

Abstract

Transepithelial K+ movement was studied in vitro in the short-circuited turtle bladder by increasing luminal K+ permeability and by inhibiting the basolateral Na/K pump. Luminal addition of amphotericin B caused net K+ secretion (180±52 nmol/h) compared with net K+ absorption (42±6 nmol/h) in control bladders. Serosal ouabain and luminal amiloride abolished K+ secretion in amphotericin-treated bladders; ouabain restored net absorption (45±16 nmol/h). The direction and rate of net K+ transport are controlled by the relative K+ permeabilities and the Na/K pump sites at the two cell membranes of the epithelium.

Authors

Russell F. Husted, Philip R. Steinmetz

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