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Evidence of Incomplete Left Ventricular Relaxation in the Dog: PREDICTION FROM THE TIME CONSTANT FOR ISOVOLUMIC PRESSURE FALL
Myron L. Weisfeldt, … , Frank C. P. Yin, James L. Weiss
Myron L. Weisfeldt, … , Frank C. P. Yin, James L. Weiss
Published December 1, 1978
Citation Information: J Clin Invest. 1978;62(6):1296-1302. https://doi.org/10.1172/JCI109250.
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Evidence of Incomplete Left Ventricular Relaxation in the Dog: PREDICTION FROM THE TIME CONSTANT FOR ISOVOLUMIC PRESSURE FALL

Abstract

Although it has been proposed that incomplete relaxation explains certain increases in left ventricular end diastolic pressure relative to volume, there has been no clear demonstration that incomplete relaxation occurs in the intact working ventricle. To identify incomplete relaxation, left ventricular pressure-dimension relationships were studied in 10 canine right heart bypass preparations during ventricular pacing. The fully relaxed, exponential diastolic pressure-dimension line for each ventricle was first determined from pressure and dimension values at the end of prolonged diastoles after interruption of pacing. For 167 beats during pacing under widely varying hemodynamic conditions, diastolic pressure-dimension values encountered this line defining the fully relaxed state during the filling period indicating that relaxation was complete before end diastole. The time constant for isovolumic exponential pressure fall (T) was determined for all beats. For this exponential function, if no diastolic filling occurred, 97% of pressure fall would be complete by 3.5 T after maximal negative dP/dt. For the 167 beats the fully relaxed pressure-dimension line was always encountered before 3.5 T.

Authors

Myron L. Weisfeldt, James W. Frederiksen, Frank C. P. Yin, James L. Weiss

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