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Citation Information: J Clin Invest. 1978;62(6):1240-1246. https://doi.org/10.1172/JCI109244.
Abstract
Clinical observations suggest that overt rhabdomyolysis may occur if severe hypophosphatemia is superimposed upon a pre-existing subclinical myopathy. To examine this possibility, a subclinical muscle cell injury was induced in 23 dogs by feeding them a phosphorus- and calorie-deficient diet until they lost 30% of their original weight. To induce acute, severe hypophosphatemia in the animals after partial starvation, 17 of the dogs were given large quantities of the same phosphorus-deficient diet in conjunction with an oral carbohydrate supplement, which together provided 140 kcal/kg per day.
Authors
J. P. Knochel, C. Barcenas, J. R. Cotton, T. J. Fuller, R. Haller, N. W. Carter
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