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Citation Information: J Clin Invest. 1974;54(6):1312-1322. https://doi.org/10.1172/JCI107877.
The Secondary Structure of Human Hageman Factor (Factor XII) and its Alteration by Activating Agents
Abstract
Hageman factor (factor XII) is activated by exposure to surfaces such as glass or by solutions of certain compounds, notably ellagic acid. Changes in the structure of Hageman factor accompanying activation have been examined in this study by circular dichroism spectroscopy. The spectrum of unactivated Hageman factor in aqueous solutions suggests that its conformation is mainly aperiodic. Various perturbants altered the conformation of Hageman factor in differing ways, demonstrating the sensitivity of Hageman factor to its environment.
Authors
Carl R. McMillin, Hidehiko Saito, Oscar D. Ratnoff, Alan G. Walton
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