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Plasma Clearance Rates and Renal Clearance of 3H-labeled Cyclic AMP and 3H-labeled Cyclic GMP in the Dog
Lawrence Blonde, … , Robert E. Wehmann, Alton L. Steiner
Lawrence Blonde, … , Robert E. Wehmann, Alton L. Steiner
Published January 1, 1974
Citation Information: J Clin Invest. 1974;53(1):163-172. https://doi.org/10.1172/JCI107534.
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Research Article

Plasma Clearance Rates and Renal Clearance of 3H-labeled Cyclic AMP and 3H-labeled Cyclic GMP in the Dog

Abstract

Previously, in an attempt to understand the mechanisms involved in the regulation of plasma cyclic nucleotides, we measured concentrations of adenosine 3′,5′-monophosphate (cAMP) and guanosine 3′,5′-monophosphate (cGMP) in plasma from selected blood vessels of anesthetized dogs. The observation that the renal venous plasma concentrations of both cyclic nucleotides were less than arterial concentrations suggested that the kidney might be an important site for the elimination of these compounds from plasma and prompted further investigation of the renal handling of these compounds.

Authors

Lawrence Blonde, Robert E. Wehmann, Alton L. Steiner

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