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The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog
D. E. Brenneman, … , E. L. Forker, Larry DenBesten
D. E. Brenneman, … , E. L. Forker, Larry DenBesten
Published June 1, 1972
Citation Information: J Clin Invest. 1972;51(6):1495-1503. https://doi.org/10.1172/JCI106946.
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Research Article

The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog

Abstract

To study the pathogenesis of cholesterol gallstones, we fed 24 adult male prairie dogs a high cholesterol, egg yolk diet. 13 control animals received a cholesterol-free diet. All animals fed the egg yolk diet formed multiple gallstones in 2-6 months' time. These stones contained cholesterol, 77±14% by dry weight. No stones ocurred in the control group.

Authors

D. E. Brenneman, William E. Connor, E. L. Forker, Larry DenBesten

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