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Citation Information: J Clin Invest. 1971;50(10):2113-2122. https://doi.org/10.1172/JCI106705.
Abstract
The proinsulin-like component comprised approximately 20% of total circulating basal immunoreactive insulin in 15 patients without islet cell tumors. 15 min after oral glucose, the concentration of the proinsulin-like component was unchanged and its percentage of the total immunoreactive insulin decreased with the acute release of the insulin component. By 2 hr after oral glucose, the concentration of the proinsulin-like component increased and the insulin component concentration decreased so that the percentage of the proinsulin-like component was essentially the same as in the basal state.
Authors
Phillip Gorden, Barry Sherman, Jesse Roth
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