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Citation Information: J Clin Invest. 1971;50(10):2056-2064. https://doi.org/10.1172/JCI106699.
Abstract
Rheumatoid synovial collagenase obtained from culture medium can be separated by Sephadex gel filtration into two peaks of enzyme activity. These have been designated as fast-moving and slow-moving rheumatoid synovial collagenases on the basis of their electrophoretic mobility on polyacrylamide gels. The slow-moving rheumatoid synovial collagenase has been highly purified by affinity chromatography on collagen conjugated to Sepharose and used to prepare a monospecific anti-synovial collagenase antiserum.
Authors
Eugene A. Bauer, Arthur Z. Eisen, John J. Jeffrey
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