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Citation Information: J Clin Invest. 1970;49(11):2139-2145. https://doi.org/10.1172/JCI106431.
Abstract
After the intraperitoneal injection into young mice of 700-800 mg/kg of salicylate, brain glucose fell to one-third or less of control values despite normal plasma glucose levels; brain lactate was nearly doubled and there were small decreases in phosphocreatine (18%) and in glycogen (17%). ATP, pyruvate, α-ketoglutarate, and glutamate were unchanged. In liver, glycogen was reduced 79% and lactate was five times higher than in control animals; glucose, glucose-6-phosphate, and ATP were unchanged.
Authors
Jean Holowach Thurston, Philip G. Pollock, Sheila K. Warren, Elizabeth M. Jones
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