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Stimulation of globin synthesis: relative responsiveness of reticulocytes and nucleated erythroid cells
Herbert S. Waxman
Herbert S. Waxman
Published April 1, 1970
Citation Information: J Clin Invest. 1970;49(4):701-707. https://doi.org/10.1172/JCI106282.
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Research Article

Stimulation of globin synthesis: relative responsiveness of reticulocytes and nucleated erythroid cells

Abstract

The effects of iron, cobalt, hemin, and plasma on hemoglobin synthesis by suspensions of rabbit reticulocytes and nucleated bone marrow cells were studied. L-Leucine-14C and sodium pyruvate-3-14C were employed to measure globin and heme synthesis, respectively. Normal plasma (or serum) was found to stimulate the rate of globin synthesis in both systems. The stimulatory effects of iron and hemin were additive to those of plasma or serum only in the reticulocytes.

Authors

Herbert S. Waxman

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