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Citation Information: J Clin Invest. 1969;48(11):2140-2155. https://doi.org/10.1172/JCI106181.
Abstract
Patients with acute leukemia were given repeated cycles consisting of infusions of methotrexate followed by “rescue” with folinic acid. Peripheral blood leukemic cells were harvested from patients before cyclical treatment, and the rates of incorporation of thymidine and of deoxyuridine into deoxyribonucleic acid (DNA) were measuared in vitro. There was no relationship between the pretreatment incorporation of either deoxynucleoside into DNA and the clinical response to therapy. Methotrexate suppressed deoxyuridine incorporation into DNA by the leukemic blasts in vitro, but the patients whose cells were most sensitive to this effect did not necessarily go into remission when treated.
Authors
William M. Hryniuk, Joseph R. Bertino
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