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Citation Information: J Clin Invest. 1969;48(5):869-877. https://doi.org/10.1172/JCI106045.
Abstract
A study of the mechanisms governing the high rate of sodium excretion per nephron characteristic of patients with chronic renal disease has been made in dogs. A “remnant kidney” was produced by 85% infarction of the left kidney while the right kidney was left intact. A bladder-splitting procedure allowed simultaneous measurement of glomerular filtration rate and the rate of sodium excretion by each kidney. The animals were fed a constant known amount of sodium chloride and 0.1 mg of 9 α-fluorohydrocortisone twice daily throughout the study.
Authors
Raymond G. Schultze, Howard S. Shapiro, Neal S. Bricker
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