Submit a comment
Citation Information: J Clin Invest. 1969;48(4):654-663. https://doi.org/10.1172/JCI106023.
Abstract
Female rats given large doses of estrone developed increased permeability of the biliary tree as determined by an increase in the biliary clearances of sucrose and mannitol. Spontaneous bile flow and the choleretic response to dehydrocholate declined. Estrone reduced the clearance of sulfobromophthalein (BSP) at low plasma concentrations as well as the absolute rate of BSP excretion when plasma levels were above those required to saturate active transport. The findings are consistent with a postulate that estrogen cholestasis may involve enhanced diffusion of materials from bile to blood in addition to inhibition of active transport in the opposite direction.
Authors
E. L. Forker
Guidelines
The Editorial Board will only consider comments that are deemed relevant and of interest to readers. The Journal will not post data that have not been subjected to peer review; or a comment that is essentially a reiteration of another comment.
- Comments appear on the Journal’s website and are linked from the original article’s web page.
- Authors are notified by email if their comments are posted.
- The Journal reserves the right to edit comments for length and clarity.
- No appeals will be considered.
- Comments are not indexed in PubMed.
Specific requirements
- Maximum length, 400 words
- Entered as plain text or HTML
- Author’s name and email address, to be posted with the comment
- Declaration of all potential conflicts of interest (even if these are not ultimately posted); see the Journal’s conflict-of-interest policy
- Comments may not include figures
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)