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Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase
Barry W. Festoff, Stanley H. Appel
Barry W. Festoff, Stanley H. Appel
Published December 1, 1968
Citation Information: J Clin Invest. 1968;47(12):2752-2758. https://doi.org/10.1172/JCI105956.
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Research Article

Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase

Abstract

Previous studies have demonstrated that electrically induced seizures in rat result in an increased brain intracellular sodium which can be decreased by treatment with sodium diphenylhydantoin (DPH). The correlation of cation transport with membrane-oriented sodium-potassium-adenosine triphosphatase (Na-K-ATPase) prompted an investigation of the effect of DPH upon ATPase enzyme activity.

Authors

Barry W. Festoff, Stanley H. Appel

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