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Citation Information: J Clin Invest. 1968;47(8):1851-1857. https://doi.org/10.1172/JCI105875.
Abstract
Blood from patients with erythrocytosis secondary to arterial hypoxemia due either to congenital heart disease or to chronic obstructive pulmonary disease was shown to have a decreased affinity for oxygen; the average oxygen pressure required to produce 50% saturation of hemoglobin with oxygen was 29.8 mm Hg (average normal, 26.3 mm Hg). Such a displacement of the blood oxygen equilibrium curve promotes the release of oxygen from blood to the tissues.
Authors
Miles J. Edwards, Miles J. Novy, Carrie-Lou Walters, James Metcalfe
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