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Citation Information: J Clin Invest. 1967;46(7):1172-1177. https://doi.org/10.1172/JCI105610.
Abstract
In previous studies it was found that renal cortical slices from rats with induced metabolic acidosis have an increased capacity to produce glucose, whereas cortical slices from rats with metabolic alkalosis manifest decreased gluconeogenesis. To evaluate the relative influence of extracellular fluid pH, [HCO3-], and carbon dioxide tension on renal gluconeogenesis, we observed glucose production by cortex from rats with induced respiratory acidosis, and by cortex taken from normal animals and incubated in acid and alkaline media.
Authors
Donald E. Kamm, Robert E. Fuisz, A. David Goodman, George F. Cahill Jr.
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