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RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
Nadine Haase, … , Babbette LaMarca, Ralf Dechend
Nadine Haase, … , Babbette LaMarca, Ralf Dechend
Published April 27, 2020
Citation Information: J Clin Invest. 2020;130(6):2928-2942. https://doi.org/10.1172/JCI99417.
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Research Article Reproductive biology Article has an altmetric score of 45

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

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Abstract

Authors

Nadine Haase, Donald J. Foster, Mark W. Cunningham, Julia Bercher, Tuyen Nguyen, Svetlana Shulga-Morskaya, Stuart Milstein, Sarfraz Shaikh, Jeff Rollins, Michaela Golic, Florian Herse, Kristin Kräker, Ivo Bendix, Meray Serdar, Hanna Napieczynska, Arnd Heuser, Alexandra Gellhaus, Kristin Thiele, Gerd Wallukat, Dominik N. Müller, Babbette LaMarca, Ralf Dechend

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Figure 2

siRNA against hAgt reduces serum angiotensinogen and angiotensin peptide levels.

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siRNA against hAgt reduces serum angiotensinogen and angiotensin peptide...
(A) Effect of luciferase-targeting siRNA or hAgt-targeting siRNA on serum hAGT levels in preeclamptic (PE) rats. Serum hAGT concentrations were significantly reduced in hAgt-targeting siRNA–treated (n = 9) versus luciferase-targeting siRNA–treated (n = 5) rats (**P < 0.01; unpaired t test; mean ± SEM). (B) Effect of luciferase-targeting siRNA or hAgt-targeting siRNA on serum rAGT levels in PE rats. Serum rAGT concentrations were significantly reduced in hAgt-targeting siRNA–treated (n = 9) versus luciferase-targeting siRNA–treated (n = 5) rats (***P < 0.001; unpaired t test; mean ± SEM). (C) Effect of luciferase-targeting siRNA or hAgt-targeting siRNA on circulating angiotensin (Ang) peptide levels in PE rats. Serum peptide concentrations of Ang 1-5, Ang 1-7, Ang 1-8, Ang 1-10, and Ang 3-8 were lower in hAgt-targeting siRNA–treated (n = 9) versus luciferase-targeting siRNA–treated (n = 5) rats (**P < 0.01, ***P < 0.001; Mann-Whitney test or unpaired t test; mean ± SEM). Serum peptide concentrations of Ang 1-9, Ang 2-7, Ang 2-8, Ang 2-10, and Ang 3-7 were unaffected.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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