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Citations to this article

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia, … , Peter Vandenabeele, Tom Vanden Berghe
Behrouz Hassannia, … , Peter Vandenabeele, Tom Vanden Berghe
Published June 25, 2018
Citation Information: J Clin Invest. 2018;128(8):3341-3355. https://doi.org/10.1172/JCI99032.
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Research Article Neuroscience Oncology Article has an altmetric score of 19

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

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Abstract

High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor–like 2 pathway through targeting of Kelch-like ECH-associated protein 1 (noncanonical ferroptosis induction) or inactivates glutathione peroxidase 4 (canonical ferroptosis induction). Noncanonical ferroptosis induction is characterized by an increase in intracellular labile Fe(II) upon excessive activation of heme oxygenase-1, which is sufficient to induce ferroptosis. This double-edged mechanism might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastoma xenografts. Nano-targeting of WA allows systemic application and suppressed tumor growth due to an enhanced accumulation at the tumor site. Collectively, our data propose a novel therapeutic strategy to efficiently kill cancer cells by ferroptosis.

Authors

Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, Tom Vanden Berghe

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Rabitha R, Shivani S, Showket Y, Sudhandiran G
World Journal of Gastroenterology 2023
Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment
Wan S, Zhang G, Liu R, Abbas MN, Cui H
Cell communication and signaling : CCS 2023
Heme: The Lord of the Iron Ring
Voltarelli VA, Alves de Souza RW, Miyauchi K, Hauser CJ, Otterbein LE
Antioxidants 2023
Research Models to Study Ferroptosis's Impact in Neurodegenerative Diseases.
Costa I, Barbosa DJ, Silva V, Benfeito S, Borges F, Remião F, Silva R
Pharmaceutics 2023
Ferritin in cancer therapy: A pleiotropic tumoraffin nanocage-based transport.
Deng G, Li Y, Liang N, Hu P, Zhang Y, Qiao L, Zhang Y, Xie J, Luo H, Wang F, Chen F, Liu F, Xu D, Zhang J
Cancer Medicine 2023
ATP2B3 Inhibition Alleviates Erastin–Induced Ferroptosis in HT-22 Cells through the P62–KEAP1–NRF2–HO-1 Pathway
Guo S, Zhong A, Zhang D, Gao J, Ni Y, Zhao R, Ma W
International journal of molecular sciences 2023
Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer
Khalil R, Green RJ, Sivakumar K, Varandani P, Bharadwaj S, Mohapatra SS, Mohapatra S
Cancers 2023
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ
Molecular Medicine 2023
Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia.
Tang X, Wang Y, Zhu Y, Guo Y, Liu B
Annals of Hematology 2023
Protein arginine methyltransferase 8 regulates ferroptosis and macrophage polarization in spinal cord injury via glial cell‐derived neurotrophic factor
Zou Z, Liu R, Wang Y, Tan H, An G, Zhang B, Wang Y, Dong D
CNS Neuroscience & Therapeutics 2023
Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps
Pacheco-Fernandez T, Markle H, Verma C, Huston R, Gannavaram S, Nakhasi HL, Satoskar AR
Research and Reports in Tropical Medicine 2023
Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)
Shao LH, Zhu L, Wang M, Ning Y, Chen FQ, Gao XQ, Yang CT, Wang HW, Li HL
International journal of molecular medicine 2023
APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy.
Xie X, Fan C, Luo B, Zhang J, Jensen LD, Burman J, Jönsson C, Ljusberg A, Larsson P, Zhao Z, Sun XF
Molecular cancer therapeutics 2023
Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression
Zheng C, Zhang B, Li Y, Liu K, Wei W, Liang S, Guo H, Ma K, Liu Y, Wang J, Liu L
Advanced Science 2023
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression.
Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T
Cell Death and Differentiation 2023
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR
Gut 2023
The role of ferroptosis in intervertebral disc degeneration
Fan C, Chu G, Yu Z, Ji Z, Kong F, Yao L, Wang J, Geng D, Wu X, Mao H
Frontiers in Cell and Developmental Biology 2023
Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance.
Ren Y, Mao X, Xu H, Dang Q, Weng S, Zhang Y, Chen S, Liu S, Ba Y, Zhou Z, Han X, Liu Z, Zhang G
Cellular and molecular life sciences : CMLS 2023
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis.
Kim JW, Lee JY, Oh M, Lee EW
Experimental & molecular medicine 2023
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner
Kim JW, Kim MJ, Han TH, Lee JY, Kim S, Kim H, Oh KJ, Kim WK, Han BS, Bae KH, Ban HS, Bae SH, Lee SC, Lee H, Lee EW
Cell Death and Disease 2023
Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer.
Wang G, Wang JJ, Zhi-Min Z, Xu XN, Shi F, Fu XL
Science Progress 2023
An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma.
Liu S, Hu Q, Xie Z, Chen S, Li Y, Quan N, Huang K, Li R, Fang L
Journal of Cancer Research and Clinical Oncology 2023
Targeting ferroptosis opens new avenues for the development of novel therapeutics.
Sun S, Shen J, Jiang J, Wang F, Min J
Signal Transduction and Targeted Therapy 2023
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases.
Li J, Zheng S, Fan Y, Tan K
Cell Death and Disease 2023
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
Xing Z, Su A, Mi L, Zhang Y, He T, Qiu Y, Wei T, Li Z, Zhu J, Wu W
Drug design, development and therapy 2023
Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).
Dar NJ, John U, Bano N, Khan S, Bhat SA
Molecular Neurobiology 2023
Molecular mechanisms of ferroptosis and its antitumor applications in natural products: Ferroptosis and applications in natural products
Yu D, Wang Q, Zhang Q, Cai M, Liu S, Zhang W
Acta Biochimica et Biophysica Sinica 2023
NRF2, a Superstar of Ferroptosis
Yan R, Lin B, Jin W, Tang L, Hu S, Cai R
Antioxidants 2023
The mechanism of ferroptosis and its related diseases
Feng S, Tang D, Wang Y, Li X, Bao H, Tang C, Dong X, Li X, Yang Q, Yan Y, Yin Z, Shang T, Zheng K, Huang X, Wei Z, Wang K, Qi S
2023
The role of HIF-1α/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy
Liang Z, Zheng Z, Guo Q, Tian M, Yang J, Liu X, Zhu X, Liu S
iScience 2023
MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS
Cell Reports 2023
Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis.
Liu H, He Y, Gao X, Li T, Qiao B, Tang L, Lan J, Su Q, Ruan Z, Tang Z, Hu L
Mycotoxin Research 2023
Ferroptosis triggers airway inflammation in asthma
Li M, Li M, Hou Y, HE H, Jiang R, Wang C, Sun S
Therapeutic advances in respiratory disease 2023
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Li Y, Du Y, Zhou Y, Chen Q, Luo Z, Ren Y, Chen X, Chen G
Cell communication and signaling : CCS 2023
Targeting Ferroptosis as a Therapeutic Implication in Lung Cancer Treatment by a Novel Naphthoquinone Inducer: Juglone.
Du J, Krishnamoorthy K, Ramabhai V, Yang D
Molecular Biotechnology 2023
Ferroptosis: a new promising target for hepatocellular carcinoma therapy.
Xu Q, Ren L, Ren N, Yang Y, Pan J, Zheng Y, Wang G
Molecular and Cellular Biochemistry 2023
Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis
Huang R, Wu J, Ma Y, Kang K
Viruses 2023
Regulation of Ferroptosis by Lipid Metabolism
Pope LE, Dixon SJ
Trends in Cell Biology 2023
Chemoprevention of neuroblastoma: progress and promise beyond uncertainties
Aravindan N, Natarajan M, Somasundaram DB, Aravindan S
Journal of Cancer Metastasis and Treatment 2023
Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.
Wang C, Yi T, Li X, Cui J, Li B, Qin Y, Tang S, Zhang J
Journal of Cellular and Molecular Medicine 2023
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills.
Consoli V, Fallica AN, Sorrenti V, Pittalà V, Vanella L
Antioxidants & Redox Signaling 2023
Assessing the cardioprotective effect of necrosulfonamide in doxorubicin-induced cardiotoxicity in mice
Abbas SF, Abdulkadim H, Hadi NR
Journal of medicine and life 2023
Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism
Chen T, Liang L, Wang Y, Li X, Yang C
Apoptosis : an international journal on programmed cell death 2023
Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1.
Gu Q, Sha W, Huang Q, Wang J, Zhu Y, Xu T, Xu Z, Zhu Q, Ge J, Tian S, Lin X
Neural Regeneration Research 2023
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury
Mann J, Reznik E, Santer M, Fongheiser MA, Smith N, Hirschhorn T, Zandkarimi F, Soni RK, Dafré AL, Miranda-Vizuete A, Farina M, Stockwell BR
Cell Chemical Biology 2023
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
Koeberle SC, Kipp AP, Stuppner H, Koeberle A
Medicinal Research Reviews 2023
Deeper insight into ferroptosis: association with Alzheimer's, Parkinson's disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis.
Yadav VK, Choudhary N, Gacem A, Verma RK, Abul Hasan M, Tarique Imam M, Almalki ZS, Yadav KK, Park HK, Ghosh T, Kumar P, Patel A, Kalasariya H, Jeon BH, Ali AlMubarak H
Redox report : communications in free radical research 2023
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu
Signal Transduction and Targeted Therapy 2022
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis
H Kitakata, J Endo, H Ikura, H Moriyama, K Shirakawa, Y Katsumata, M Sano
International journal of molecular sciences 2022
Metabolic regulation of ferroptosis in the tumor microenvironment
N Mbah, C Lyssiotis
The Journal of biological chemistry 2022
Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products
C Ge, S Zhang, H Mu, S Zheng, Z Tan, X Huang, C Xu, J Zou, Y Zhu, D Feng, J Aa
Frontiers in Cell and Developmental Biology 2022
Potential Role of APEX1 During Ferroptosis
N Guo, Y Chen, Y Zhang, Y Deng, F Zeng, X Li
Frontiers in Oncology 2022
Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics
J Huang, J Zhang, J Ma, J Ma, J Liu, F Wang, X Tang, H Moreira
Oxidative Medicine & Cellular Longevity 2022
Ferroptosis and ferritinophagy in diabetes complications
J He, Z Li, P Xia, A Shi, X FuChen, J Zhang, P Yu
Molecular Metabolism 2022
COVID-19-Related Brain Injury: The Potential Role of Ferroptosis
R Zhang, C Sun, X Chen, Y Han, W Zang, C Jiang, J Wang, J Wang
Journal of inflammation research 2022
Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
J Deng, M Zhou, T Liao, W Kuang, H Xia, Z Yin, Q Tan, Y Li, S Song, E Zhou, Y Jin
Frontiers in Cell and Developmental Biology 2022
Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types
B Tang, R Yan, J Zhu, S Cheng, C Kong, W Chen, S Fang, Y Wang, Y Yang, R Qiu, C Lu, J Ji
International journal of biological sciences 2022
Induction and application of ferroptosis in cancer therapy
Q Nie, Y Hu, X Yu, X Li, X Fang
Cancer Cell International 2022
Role of Ferroptosis in Stroke
Y Xu, K Li, Y Zhao, L Zhou, Y Liu, J Zhao
Cellular and Molecular Neurobiology 2022
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis
L Lin, M Zhang, L Zhang, D Zhang, C Li, Y Li
Frontiers in Cell and Developmental Biology 2022
Ferroptosis in cancer and cancer immunotherapy
L Zhao, X Zhou, F Xie, L Zhang, H Yan, J Huang, C Zhang, F Zhou, J Chen, L Zhang
2022
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
B Cakir, Y Tanaka, F Kiral, Y Xiang, O Dagliyan, J Wang, M Lee, A Greaney, W Yang, C duBoulay, M Kural, B Patterson, M Zhong, J Kim, Y Bai, W Min, L Niklason, P Patra, I Park
Nature Communications 2022
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
A Singh, A Raza, S Amin, C Damodaran, A Sharma
Molecules (Basel, Switzerland) 2022
Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway
L Zhang, C Li, Y Zhang, J Zhang, X Yang
Oncology Letters 2022
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
S Coillie, E San, I Goetschalckx, B Wiernicki, B Mukhopadhyay, W Tonnus, S Choi, R Roelandt, C Dumitrascu, L Lamberts, G Dams, W Weyts, J Huysentruyt, B Hassannia, I Ingold, S Lele, E Meyer, M Berg, R Seurinck, Y Saeys, A Vermeulen, A van Nuijs, M Conrad, A Linkermann, M Rajapurkar, P Vandenabeele, E Hoste, K Augustyns, T Berghe
Nature Communications 2022
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma
L Qiu, R Zhou, Z Luo, J Wu, H Jiang
Frontiers in Oncology 2022
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
A Jo, J Bae, Y Yoon, T Chung, E Lee, Y Kim, H Joh, J Chung
Cell Death and Disease 2022
Targeting ferroptosis as a vulnerability in cancer
G Lei, L Zhuang, B Gan
Nature Reviews Cancer 2022
Ferroptosis Biology and Implication in Cancers
C Qu, Y Peng, S Liu
Frontiers in Molecular Biosciences 2022
Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells
S Pandrangi, P Chittineedi, S Chalumuri, A Meena, J Mosquera, S Llaguno, R Pamuru, G Mohiddin, A Mohammad
Molecules (Basel, Switzerland) 2022
Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis
C Feng, Y Wu, Y Chen, X Xiong, P Li, X Peng, C Li, W Weng, Y Zhu, D Zhou, Y Li
Molecular Biology Reports 2022
Regulatory pathways and drugs associated with ferroptosis in tumors
D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo, P Wu, X Deng, L Li, S Zuo, Q Yan, S Zhang, F Wang, L Shi, X Li, B Xiang, M Zhou, Q Liao, C Guo, Z Zeng, W Xiong, Z Gong
Cell Death and Disease 2022
Ferroptosis and Its Potential Role in the Nervous System Diseases
Zhou Y, Lin W, Rao T, Zheng J, Zhang T, Zhang M, Lin Z
Journal of inflammation research 2022
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity.
Wiernicki B, Maschalidi S, Pinney J, Adjemian S, Vanden Berghe T, Ravichandran KS, Vandenabeele P
Nature Communications 2022
Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma
Ferrada L, Barahona MJ, Salazar K, Godoy AS, Vera M, Nualart F
Frontiers in Oncology 2022
Iron Transporters and Ferroptosis in Malignant Brain Tumors
Zhao J, Wang Y, Tao L, Chen L
Frontiers in Oncology 2022
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1
Shi H, Hou B, Li H, Zhou H, Du B
Frontiers in pharmacology 2022
Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction
Liang X, Hu C, Han M, Liu C, Sun X, Yu K, Gu H, Zhang J
Frontiers in Oncology 2022
Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
Lai X, Sun Y, Zhang X, Wang D, Wang J, Wang H, Zhao Y, Liu X, Xu X, Song H, Ping W, Sun Y, Hu Z
Frontiers in pharmacology 2022
Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases
Cui C, Yang F, Li Q
Frontiers in Molecular Biosciences 2022
Ferroptosis-related local immune cytolytic activity in tumor microenvironment of basal cell and squamous cell carcinoma
Wang J, Xie D, Wu H, Li Y, Wan C
Aging 2022
Therapeutic Implications of Ferroptosis in Renal Fibrosis
Zhang Y, Mou Y, Zhang J, Suo C, Zhou H, Gu M, Wang Z, Tan R
Frontiers in Molecular Biosciences 2022
Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes
Kim DH, Choi HI, Park JS, Kim CS, Bae EH, Ma SK, Kim SW
Redox Biology 2022
Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment
de Souza I, Ramalho MC, Guedes CB, Osawa IY, Monteiro LK, Gomes LR, Rocha CR
International journal of molecular sciences 2022
Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
Fernández-Acosta R, Iriarte-Mesa C, Alvarez-Alminaque D, Hassannia B, Wiernicki B, Díaz-García AM, Vandenabeele P, Vanden Berghe T, Pardo Andreu GL
Molecules (Basel, Switzerland) 2022
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation
de Souza I, Monteiro LK, Guedes CB, Silva MM, Andrade-Tomaz M, Contieri B, Latancia MT, Mendes D, Porchia BF, Lazarini M, Gomes LR, Rocha CR
Cell Death and Disease 2022
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra J, Kodavati M, Provasek VE, Rao KS, Mitra S, Hamilton DJ, Horner PJ, Vahidy FS, Britz GW, Kent TA, Hegde ML
Ageing Research Reviews 2022
Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers
Feng J, Wang J, Wang Y, Huang X, Shao T, Deng X, Cao Y, Zhou M, Zhao C
Frontiers in Cell and Developmental Biology 2022
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing
Pontel LB, Bueno-Costa A, Morellato AE, Carvalho Santos J, Roué G, Esteller M
Redox Biology 2022
Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field
Cheng K, Guo Q, Shen Z, Yang W, Zhou Y, Sun Z, Yao X, Wu H
Frontiers in Oncology 2022
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response
De Backer J, Maric D, Zuhra K, Bogaerts A, Szabo C, Vanden Berghe W, Hoogewijs D
Antioxidants 2022
Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer
Meng Y, Sun H, Li Y, Zhao S, Su J, Zeng F, Deng G, Chen X
International journal of biological sciences 2022
Ferroptosis-related gene signatures in neuroblastoma associated with prognosis
Chen Y, Li Z, Cao Q, Guan H, Mao L, Zhao M
Frontiers in Cell and Developmental Biology 2022
Microenvironment immune response induced by tumor ferroptosis—the application of nanomedicine
Yun T, Liu Z, Wang J, Wang R, Zhu L, Zhu Z, Wang X
Frontiers in Oncology 2022
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns.
Qu L, He X, Tang Q, Fan X, Liu J, Lin A
Journal of Zhejiang University. Science. B 2022
Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells.
Mi XJ, Park HR, Dhandapani S, Lee S, Kim YJ
International journal of biological sciences 2022
Ferroptosis Induction and YAP Inhibition as New Therapeutic Targets in Gastrointestinal Stromal Tumors (GISTs)
Delvaux M, Hagué P, Craciun L, Wozniak A, Demetter P, Schöffski P, Erneux C, Vanderwinden JM
Cancers 2022
Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer
Zhang M, Liu Z, Le Y, Gu Z, Zhao H
Oxidative medicine and cellular longevity 2022
The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
Zhang W, Li X, Xu J, Wang Y, Xing Z, Hu S, Fan Q, Lu S, Cheng J, Gu J, Cai R
Cancers 2022
Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis
Li Y, Zhu Z, Cui H, Ding K, Zhao Y, Ma X, Adetunji AO, Min L
2022
The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
Ma J, Zhang H, Chen Y, Liu X, Tian J, Shen W
Biomolecules 2022
Targeting lipid metabolism for ferroptotic cancer therapy.
Luo M, Yan J, Hu X, Li H, Li H, Liu Q, Chen Y, Zou Z
Apoptosis : an international journal on programmed cell death 2022
The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
Huo C, Li G, Hu Y, Sun H
International journal of molecular sciences 2022
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10
Chen W, Yang W, Zhang C, Liu T, Zhu J, Wang H, Li T, Jin A, Ding L, Xian J, Tian T, Pan B, Guo W, Wang B
Oxidative medicine and cellular longevity 2022
Functional Validation of the Putative Oncogenic Activity of PLAU
Sarno F, Goubert D, Logie E, Rutten MG, Koncz M, Deben C, Niemarkt AE, Altucci L, Verschure PJ, Kiss A, Berghe WV, Rots MG
Biomedicines 2022
Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers.
Rashad S, Byrne SR, Saigusa D, Xiang J, Zhou Y, Zhang L, Begley TJ, Tominaga T, Niizuma K
Neuroscience 2022
An iron-dependent form of non-canonical ferroptosis induced by labile iron.
Li Y, Ouyang Q, Chen W, Liu K, Zhang B, Yao J, Zhang S, Ding J, Cong M, Xu A
Science China Life Sciences 2022
Gene interfered-ferroptosis therapy for cancers
J Gao, T Luo, J Wang
Nature Communications 2021
Ferroptosis-mediated Crosstalk in the Tumor Microenvironment Implicated in Cancer Progression and Therapy
Y Liu, C Duan, R Dai, Y Zeng
Frontiers in Cell and Developmental Biology 2021
Ferroptosis: Mechanism and Diseases
AF Florez, H Alborzinia
2021
Ferroptosis: Mechanism and Diseases
AF Florez, H Alborzinia
2021
A Novel Ferroptosis-Associated Gene Signature to Predict Prognosis in Patients with Uveal Melanoma
H Luo, C Ma
Diagnostics 2021
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
W Liao, W Yang, Z Shen, W Ai, Q Pan, Y Sun, S Guo
Diabetes 2021
Ferroptosis: mechanisms and links with diseases
H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi, P Lei
Signal Transduction and Targeted Therapy 2021
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
V Consoli, V Sorrenti, S Grosso, L Vanella
Biomolecules 2021
Molecular mechanisms of cell death in neurological diseases
D Moujalled, A Strasser, JR Liddell
Cell Death and Differentiation 2021
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Z Tang, Y Ju, X Dai, N Ni, Y Liu, D Zhang, H Gao, H Sun, J Zhang, P Gu
Redox Biology 2021
The Multifaceted Regulation of Mitochondria in Ferroptosis
H Wu, F Wang, N Ta, T Zhang, W Gao
Life Sciences 2021
Emerging mechanisms and targeted therapy of ferroptosis in cancer
H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang, Y Tao
Molecular Therapy 2021
Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
JC Rodriguez-Gonzalez, I Hernández-Balmaseda, K Declerck, C Pérez-Novo, E Logie, C Theys, P Jakubek, OL Quiñones-Maza, G Dantas-Cassali, DC dos Reis, GV Camp, MT Paz, I Rodeiro-Guerra, R Delgado-Hernández, WV Berghe
Frontiers in pharmacology 2021
Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer
G Greco, E Catanzaro, C Fimognari
Cancers 2021
Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
R Das, A Rauf, S Akhter, MN Islam, TB Emran, S Mitra, IN Khan, MS Mubarak
Molecules (Basel, Switzerland) 2021
Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
R Huang, R Dong, N Wang, Y He, P Zhu, C Wang, B Lan, Y Gao, L Sun
Cellular and Molecular Neurobiology 2021
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival
SK Chiang, SE Chen, LC Chang
Cells 2021
Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy
C Bartolacci, C Andreani, Y El-Gammal, PP Scaglioni
Frontiers in Molecular Biosciences 2021
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Q Tan, Y Fang, Q Gu
Frontiers in pharmacology 2021
Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action
Y Fang, X Chen, Q Tan, H Zhou, J Xu, Q Gu
ACS Central Science 2021
Ferroptosis Meets Cell–Cell Contacts
C Dietrich, TG Hofmann
Cells 2021
Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage
MY Li, XH Dai, XP Yu, W Zou, W Teng, P Liu, XY Yu, Q An, X Wen
Journal of Molecular Neuroscience 2021
Ferroptosis: mechanisms, biology and role in disease
X Jiang, BR Stockwell, M Conrad
Nature Reviews Molecular Cell Biology 2021
Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation
VE Kagan, YY Tyurina, II Vlasova, AA Kapralov, AA Amoscato, TS Anthonymuthu, VA Tyurin, IH Shrivastava, FB Cinemre, A Lamade, MW Epperly, JS Greenberger, DH Beezhold, RK Mallampalli, AK Srivastava, H Bayir, AA Shvedova
Frontiers in Endocrinology 2021
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice
X Feng, S Wang, Z Sun, H Dong, H Yu, M Huang, X Gao
Frontiers in Endocrinology 2021
Clinical Significance of Heme Oxygenase 1 in Tumor Progression
M Nitti, C Ivaldo, N Traverso, AL Furfaro
Antioxidants 2021
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
B Li, S Wei, L Yang, X Peng, Y Ma, B Wu, Q Fan, S Yang, X Li, H Jin, S Tang, M Huang, H Li, J Liu
Frontiers in Oncology 2021
Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma
X Zhu, Y Zhou, Y Ou, Z Cheng, D Han, Z Chu, S Pan
Aging 2021
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
A Beatty, T Singh, YY Tyurina, VA Tyurin, S Samovich, E Nicolas, K Maslar, Y Zhou, KQ Cai, Y Tan, S Doll, M Conrad, A Subramanian, H Bayır, VE Kagan, U Rennefahrt, JR Peterson
Nature Communications 2021
Nanoparticles for Ferroptosis Therapy in Cancer
N Zaffaroni, GL Beretta
Pharmaceutics 2021
Ferroptosis‐related gene signature predicts prognosis and immunotherapy in glioma
RJ Wan, W Peng, QX Xia, HH Zhou, XY Mao
CNS Neuroscience & Therapeutics 2021
Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
LF Boullosa, JV Loenhout, T Flieswasser, JD Waele, C Hermans, H Lambrechts, B Cuypers, K Laukens, E Bartholomeus, V Siozopoulou, WH Vos, M Peeters, EL Smits, C Deben
Redox Biology 2021
Epigenomic regulation by labile iron
V Camarena, TC Huff, G Wang
Free radical biology & medicine 2021
Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells
L Zhang, J Zhang, Y Jin, G Yao, H Zhao, P Qiao, S Wu
Frontiers in Cell and Developmental Biology 2021
A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data
R Odongo, A Demiroglu-Zergeroglu, T Çakır
2021
Ferroptosis, radiotherapy, and combination therapeutic strategies
G Lei, C Mao, Y Yan, L Zhuang, B Gan
Protein & Cell 2021
Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer
S Gaikwad, SK Srivastava
Antioxidants 2021
Ferroptosis Patterns Correlate with Immune Microenvironment Characterization in Gastric Cancer
X Jiang, F Liu, P Liu, Y Yan, S Lan, K Zhuang, Y Liu, K Jiang, Y Huang, K Nie, Z Zheng, J Pan, J Zheng, F Liu, S Xu, P Li, Y Wen
International journal of general medicine 2021
Implication of ferroptosis in aging
M Mazhar, AU Din, H Ali, G Yang, W Ren, L Wang, X Fan, S Yang
Cell Death Discovery 2021
Lipid Metabolism and Ferroptosis
JY Lee, WK Kim, KH Bae, SC Lee, EW Lee
Biology : open access journal 2021
Broadening horizons: the role of ferroptosis in cancer
X Chen, R Kang, G Kroemer, D Tang
Nature Reviews Clinical Oncology 2021
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
R Wei, Y Zhao, J Wang, X Yang, S Li, Y Wang, X Yang, J Fei, X Hao, Y Zhao, L Gui, X Ding
International journal of biological sciences 2021
Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma
JV Loenhout, LF Boullosa, D Quatannens, JD Waele, C Merlin, H Lambrechts, HW Lau, C Hermans, A Lin, F Lardon, M Peeters, A Bogaerts, E Smits, C Deben
Cells 2021
Research progress on the occurrence and therapeutic mechanism of ferroptosis in NSCLC
Y Zhang, R Guo, J Li, L Zhu
Naunyn-Schmiedeberg's Archives of Pharmacology 2021
Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular Senescence
E Logie, BV Puyvelde, B Cuypers, A Schepers, H Berghmans, J Verdonck, K Laukens, L Godderis, M Dhaenens, D Deforce, WV Berghe
International journal of molecular sciences 2021
Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1
S Li, Y Zhou, Q Huang, X Fu, L Zhang, F Gao, Z Jin, L Wu, C Shu, X Zhang, W Xu, J Shu
Cell Death Discovery 2021
Phosphocatalytic Kinome Activity Profiling of Apoptotic and Ferroptotic Agents in Multiple Myeloma Cells
E Logie, CP Novo, A Driesen, PV Vlierberghe, WV Berghe
International journal of molecular sciences 2021
Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
M Dahlmanns, E Yakubov, JK Dahlmanns
Frontiers in Oncology 2021
Regulated cell death: discovery, features and implications for neurodegenerative diseases
J Cui, S Zhao, Y Li, D Zhang, B Wang, J Xie, J Wang
Cell Communication and Signaling 2021
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1
T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, S Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang
2021
Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
E Dai, L Han, J Liu, Y Xie, HJ Zeh, R Kang, L Bai, D Tang
Nature Communications 2020
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway
J Liu, C Zhang, J Wang, W Hu, Z Feng
International journal of molecular sciences 2020
Novel insights on targeting ferroptosis in cancer therapy
S Zuo, J Yu, H Pan, L Lu
Biomarker Research 2020
Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
JD Puentes-Pardo, S Moreno-SanJuan, Á Carazo, J León
Antioxidants 2020
Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells
RE Kim, CY Shin, SH Han, KJ Kwon
International journal of molecular sciences 2020
Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry
Nature Reviews Clinical Oncology 2020
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
E Logie, WV Berghe
Antioxidants 2020
Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?
M Serra, A Columbano, U Ammarah, M Mazzone, A Menga
Frontiers in Oncology 2020
Ferroptosis in Cancer Treatment: Another Way to Rome
Y Wu, C Yu, M Luo, C Cen, J Qiu, S Zhang, K Hu
Frontiers in Oncology 2020
Ferroptosis: machinery and regulation
X Chen, J Li, R Kang, DJ Klionsky, D Tang
Autophagy 2020
Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
T Behl, A Sharma, L Sharma, A Sehgal, G Zengin, R Brata, O Fratila, S Bungau
Biomedicines 2020
Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective
M Dom, WV Berghe, XV Ostade
2020
Heme Oxygenase-1 in Central Nervous System Malignancies
G Sferrazzo, MD Rosa, E Barone, GL Volti, N Musso, D Tibullo, I Barbagallo
Journal of Clinical Medicine 2020
Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers
M Jiang, M Qiao, C Zhao, J Deng, X Li, C Zhou
Translational Lung Cancer Research 2020
Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches
DA Armenta, SJ Dixon
Cell Chemical Biology 2020
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
P Dharmalingam, G Talakatta, J Mitra, H Wang, PJ Derry, LG Nilewski, EA McHugh, RH Fabian, K Mendoza, V Vasquez, PM Hegde, E Kakadiaris, T Roy, I Boldogh, VL Hegde, S Mitra, JM Tour, TA Kent, ML Hegde
ACS Nano 2020
The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury
Y Chen, S Liu, J Li, Z Li, J Quan, X Liu, Y Tang, B Liu
Oxidative medicine and cellular longevity 2020
Targeting ferroptosis in breast cancer
Z Li, L Chen, C Chen, Y Zhou, D Hu, J Yang, Y Chen, W Zhuo, M Mao, X Zhang, L Xu, L Wang, J Zhou
Biomarker Research 2020
Ferroptosis: An emerging therapeutic opportunity for cancer
L Wang, X Chen, C Yan
Genes & Diseases 2020
Emerging immune and cell death mechanisms in stroke: Saponins as therapeutic candidates
L García-Pupo, EV San, R Delgado-Hernández, TV Berghe, WV Berghe
2020
Ferroptosis: molecular mechanisms and health implications
D Tang, X Chen, R Kang, G Kroemer
Cell Research 2020
Ferroptosis in Cancer Cell Biology
CM Bebber, F Müller, LP Clemente, J Weber, S von Karstedt
Cancers 2020
[Mechanism of Ferroptosis and Its Research Progress in Lung Cancer]
Jinming Wu, Lifang Ma, Jiayi Wang, Yongxia Qiao
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2020
Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease
N Tao, K Li, J Liu
Oxidative medicine and cellular longevity 2020
Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction
I Weigand, J Schreiner, F Röhrig, N Sun, LS Landwehr, H Urlaub, S Kendl, K Kiseljak-Vassiliades, ME Wierman, JP Angeli, A Walch, S Sbiera, M Fassnacht, M Kroiss
Cell Death and Disease 2020
Systems biology of ferroptosis: A modeling approach
A Konstorum, L Tesfay, BT Paul, FM Torti, RC Laubenbacher, SV Torti
Journal of Theoretical Biology 2020
Chronic activation of anti‐oxidant pathways and iron accumulation in epileptogenic malformations
TS Zimmer, G Ciriminna, A Arena, JJ Anink, A Korotkov, FE Jansen, W Hecke, WG Spliet, PC Rijen, JC Baayen, S Idema, NR Rensing, M Wong, JD Mills, EA Vliet, E Aronica
Neuropathology and Applied Neurobiology 2020
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
X Song, D Long
Frontiers in neuroscience 2020
Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
K Subburayan, F Thayyullathil, S Pallichankandy, AR Cheratta, S Galadari
Translational oncology 2020
Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer
Z Liu, Q Zhao, ZX Zuo, SQ Yuan, K Yu, Q Zhang, X Zhang, H Sheng, HQ Ju, H Cheng, F Wang, RH Xu, ZX Liu
iScience 2020
Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
J Lippmann, K Petri, S Fulda, J Liese
Translational oncology 2020
Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID‐19): autopsy reveals a ferroptosis signature
W Jacobs, M Lammens, A Kerckhofs, E Voets, EV San, SV Coillie, C Peleman, M Mergeay, S Sirimsi, V Matheeussen, H Jansens, I Baar, TV Berghe, PG Jorens
ESC Heart Failure 2020
Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
D Hahn, SH Shin, JS Bae
Antioxidants 2020
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
I Efimova, E Catanzaro, LV der Meeren, VD Turubanova, H Hammad, TA Mishchenko, MV Vedunova, C Fimognari, C Bachert, F Coppieters, S Lefever, AG Skirtach, O Krysko, DV Krysko
Journal for ImmunoTherapy of Cancer 2020
Transcription factors in ferroptotic cell death
C Dai, X Chen, J Li, P Comish, R Kang, D Tang
Cancer Gene Therapy 2020
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis
A Anandhan, M Dodson, CJ Schmidlin, P Liu, DD Zhang
Cell Chemical Biology 2020
SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?
M Yang, CL Lai
Cell Death Discovery 2020
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
B Wiernicki, H Dubois, YY Tyurina, B Hassannia, H Bayir, VE Kagan, P Vandenabeele, A Wullaert, TV Berghe
Cell Death and Disease 2020
Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis
OS Kwon, EJ Kwon, HJ Kong, JY Choi, YJ Kim, EW Lee, W Kim, H Lee, HJ Cha
Redox Biology 2020
Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology
RA Brown, KL Richardson, TD Kabir, D Trinder, R Ganss, PJ Leedman
Frontiers in Oncology 2020
Discovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo
Y Xia, S Liu, C Li, Z Ai, W Shen, W Ren, X Yang
Cell Death and Disease 2020
The Chemistry and Biology of Ferroptosis
BR Stockwell, X Jiang
Cell Chemical Biology 2020
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo, F Biamonte
Cells 2020
The pathological role of ferroptosis in ischemia/reperfusion-related injury
HF Yan, QZ Tuo, QZ Yin, P Lei
Zoological Research 2020
Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib
X Song, X Wang, Z Liu, Z Yu
Frontiers in Oncology 2020
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
J Angeli, D Krysko, M Conrad
Nature Reviews Cancer 2019
Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model
ZP Acker, GA Raemdonck, E Logie, SI Acker, G Baggerman, WV Berghe, P Ponsaerts, S Dewilde
Cells 2019
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
Y Li, D Feng, Z Wang, Y Zhao, R Sun, D Tian, D Liu, F Zhang, S Ning, J Yao, X Tian
Cell Death and Differentiation 2019
The molecular machinery of regulated cell death
D Tang, R Kang, TV Berghe, P Vandenabeele, G Kroemer
Cell Research 2019
The chemical basis of ferroptosis
M Conrad, DA Pratt
Nature Chemical Biology 2019
Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
S Sui, J Zhang, S Xu, Q Wang, P Wang, D Pang
Cell Death and Disease 2019
Pro‐apoptotic effect of haem oxygenase‐1 in human colorectal carcinoma cells via endoplasmic reticular stress
MS Wu, CC Chien, J Chang, YC Chen
Journal of Cellular and Molecular Medicine 2019
Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells
GA Malfa, B Tomasello, R Acquaviva, C Genovese, AL Mantia, FP Cammarata, M Ragusa, M Renis, CD Giacomo
International journal of molecular sciences 2019
Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
TJ Park, JH Park, GS Lee, JY Lee, JH Shin, MW Kim, YS Kim, JY Kim, KJ Oh, BS Han, WK Kim, Y Ahn, JH Moon, J Song, KH Bae, DH Kim, EW Lee, SC Lee
Cell Death and Disease 2019
Ferroptosis and Its Role in Diverse Brain Diseases
A Weiland, Y Wang, W Wu, , X Han, Q Li, J Wang
Molecular Neurobiology 2018
A Dual Role of Heme Oxygenase-1 in Cancer Cells
SK Chiang, SE Chen, LC Chang
International journal of molecular sciences 2018
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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