High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor–like 2 pathway through targeting of Kelch-like ECH-associated protein 1 (noncanonical ferroptosis induction) or inactivates glutathione peroxidase 4 (canonical ferroptosis induction). Noncanonical ferroptosis induction is characterized by an increase in intracellular labile Fe(II) upon excessive activation of heme oxygenase-1, which is sufficient to induce ferroptosis. This double-edged mechanism might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastoma xenografts. Nano-targeting of WA allows systemic application and suppressed tumor growth due to an enhanced accumulation at the tumor site. Collectively, our data propose a novel therapeutic strategy to efficiently kill cancer cells by ferroptosis.
Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y. Tyurina, Hülya Bayır, Behnaz A. Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V. Krysko, Paul G. Ekert, Simone Fulda, Bruno G. De Geest, Marcus Conrad, Valerian E. Kagan, Wim Vanden Berghe, Peter Vandenabeele, Tom Vanden Berghe
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2023 | |
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2023 | |
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Annals of Hematology | 2023 |
Protein arginine methyltransferase 8 regulates ferroptosis and macrophage polarization in spinal cord injury via glial cell‐derived neurotrophic factor
Zou Z, Liu R, Wang Y, Tan H, An G, Zhang B, Wang Y, Dong D |
CNS Neuroscience & Therapeutics | 2023 |
Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps
Pacheco-Fernandez T, Markle H, Verma C, Huston R, Gannavaram S, Nakhasi HL, Satoskar AR |
Research and Reports in Tropical Medicine | 2023 |
Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)
Shao LH, Zhu L, Wang M, Ning Y, Chen FQ, Gao XQ, Yang CT, Wang HW, Li HL |
International journal of molecular medicine | 2023 |
APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy.
Xie X, Fan C, Luo B, Zhang J, Jensen LD, Burman J, Jönsson C, Ljusberg A, Larsson P, Zhao Z, Sun XF |
Molecular cancer therapeutics | 2023 |
Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression
Zheng C, Zhang B, Li Y, Liu K, Wei W, Liang S, Guo H, Ma K, Liu Y, Wang J, Liu L |
Advanced Science | 2023 |
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression.
Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T |
Cell Death and Differentiation | 2023 |
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR |
Gut | 2023 |
The role of ferroptosis in intervertebral disc degeneration
Fan C, Chu G, Yu Z, Ji Z, Kong F, Yao L, Wang J, Geng D, Wu X, Mao H |
Frontiers in Cell and Developmental Biology | 2023 |
Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance.
Ren Y, Mao X, Xu H, Dang Q, Weng S, Zhang Y, Chen S, Liu S, Ba Y, Zhou Z, Han X, Liu Z, Zhang G |
Cellular and molecular life sciences : CMLS | 2023 |
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis.
Kim JW, Lee JY, Oh M, Lee EW |
Experimental & molecular medicine | 2023 |
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner
Kim JW, Kim MJ, Han TH, Lee JY, Kim S, Kim H, Oh KJ, Kim WK, Han BS, Bae KH, Ban HS, Bae SH, Lee SC, Lee H, Lee EW |
Cell Death and Disease | 2023 |
Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer.
Wang G, Wang JJ, Zhi-Min Z, Xu XN, Shi F, Fu XL |
Science Progress | 2023 |
An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma.
Liu S, Hu Q, Xie Z, Chen S, Li Y, Quan N, Huang K, Li R, Fang L |
Journal of Cancer Research and Clinical Oncology | 2023 |
Targeting ferroptosis opens new avenues for the development of novel therapeutics.
Sun S, Shen J, Jiang J, Wang F, Min J |
Signal Transduction and Targeted Therapy | 2023 |
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases.
Li J, Zheng S, Fan Y, Tan K |
Cell Death and Disease | 2023 |
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
Xing Z, Su A, Mi L, Zhang Y, He T, Qiu Y, Wei T, Li Z, Zhu J, Wu W |
Drug design, development and therapy | 2023 |
Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).
Dar NJ, John U, Bano N, Khan S, Bhat SA |
Molecular Neurobiology | 2023 |
Molecular mechanisms of ferroptosis and its antitumor applications in natural products: Ferroptosis and applications in natural products
Yu D, Wang Q, Zhang Q, Cai M, Liu S, Zhang W |
Acta Biochimica et Biophysica Sinica | 2023 |
NRF2, a Superstar of Ferroptosis
Yan R, Lin B, Jin W, Tang L, Hu S, Cai R |
Antioxidants | 2023 |
The mechanism of ferroptosis and its related diseases
Feng S, Tang D, Wang Y, Li X, Bao H, Tang C, Dong X, Li X, Yang Q, Yan Y, Yin Z, Shang T, Zheng K, Huang X, Wei Z, Wang K, Qi S |
2023 | |
The role of HIF-1α/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy
Liang Z, Zheng Z, Guo Q, Tian M, Yang J, Liu X, Zhu X, Liu S |
iScience | 2023 |
MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS |
Cell Reports | 2023 |
Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis.
Liu H, He Y, Gao X, Li T, Qiao B, Tang L, Lan J, Su Q, Ruan Z, Tang Z, Hu L |
Mycotoxin Research | 2023 |
Ferroptosis triggers airway inflammation in asthma
Li M, Li M, Hou Y, HE H, Jiang R, Wang C, Sun S |
Therapeutic advances in respiratory disease | 2023 |
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Li Y, Du Y, Zhou Y, Chen Q, Luo Z, Ren Y, Chen X, Chen G |
Cell communication and signaling : CCS | 2023 |
Targeting Ferroptosis as a Therapeutic Implication in Lung Cancer Treatment by a Novel Naphthoquinone Inducer: Juglone.
Du J, Krishnamoorthy K, Ramabhai V, Yang D |
Molecular Biotechnology | 2023 |
Ferroptosis: a new promising target for hepatocellular carcinoma therapy.
Xu Q, Ren L, Ren N, Yang Y, Pan J, Zheng Y, Wang G |
Molecular and Cellular Biochemistry | 2023 |
Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis
Huang R, Wu J, Ma Y, Kang K |
Viruses | 2023 |
Regulation of Ferroptosis by Lipid Metabolism
Pope LE, Dixon SJ |
Trends in Cell Biology | 2023 |
Chemoprevention of neuroblastoma: progress and promise beyond uncertainties
Aravindan N, Natarajan M, Somasundaram DB, Aravindan S |
Journal of Cancer Metastasis and Treatment | 2023 |
Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer.
Wang C, Yi T, Li X, Cui J, Li B, Qin Y, Tang S, Zhang J |
Journal of Cellular and Molecular Medicine | 2023 |
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills.
Consoli V, Fallica AN, Sorrenti V, Pittalà V, Vanella L |
Antioxidants & Redox Signaling | 2023 |
Assessing the cardioprotective effect of necrosulfonamide in doxorubicin-induced cardiotoxicity in mice
Abbas SF, Abdulkadim H, Hadi NR |
Journal of medicine and life | 2023 |
Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism
Chen T, Liang L, Wang Y, Li X, Yang C |
Apoptosis : an international journal on programmed cell death | 2023 |
Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1.
Gu Q, Sha W, Huang Q, Wang J, Zhu Y, Xu T, Xu Z, Zhu Q, Ge J, Tian S, Lin X |
Neural Regeneration Research | 2023 |
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury
Mann J, Reznik E, Santer M, Fongheiser MA, Smith N, Hirschhorn T, Zandkarimi F, Soni RK, Dafré AL, Miranda-Vizuete A, Farina M, Stockwell BR |
Cell Chemical Biology | 2023 |
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
Koeberle SC, Kipp AP, Stuppner H, Koeberle A |
Medicinal Research Reviews | 2023 |
Deeper insight into ferroptosis: association with Alzheimer's, Parkinson's disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis.
Yadav VK, Choudhary N, Gacem A, Verma RK, Abul Hasan M, Tarique Imam M, Almalki ZS, Yadav KK, Park HK, Ghosh T, Kumar P, Patel A, Kalasariya H, Jeon BH, Ali AlMubarak H |
Redox report : communications in free radical research | 2023 |
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu |
Signal Transduction and Targeted Therapy | 2022 |
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis
H Kitakata, J Endo, H Ikura, H Moriyama, K Shirakawa, Y Katsumata, M Sano |
International journal of molecular sciences | 2022 |
Metabolic regulation of ferroptosis in the tumor microenvironment
N Mbah, C Lyssiotis |
The Journal of biological chemistry | 2022 |
Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products
C Ge, S Zhang, H Mu, S Zheng, Z Tan, X Huang, C Xu, J Zou, Y Zhu, D Feng, J Aa |
Frontiers in Cell and Developmental Biology | 2022 |
Potential Role of APEX1 During Ferroptosis
N Guo, Y Chen, Y Zhang, Y Deng, F Zeng, X Li |
Frontiers in Oncology | 2022 |
Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics
J Huang, J Zhang, J Ma, J Ma, J Liu, F Wang, X Tang, H Moreira |
Oxidative Medicine & Cellular Longevity | 2022 |
Ferroptosis and ferritinophagy in diabetes complications
J He, Z Li, P Xia, A Shi, X FuChen, J Zhang, P Yu |
Molecular Metabolism | 2022 |
COVID-19-Related Brain Injury: The Potential Role of Ferroptosis
R Zhang, C Sun, X Chen, Y Han, W Zang, C Jiang, J Wang, J Wang |
Journal of inflammation research | 2022 |
Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
J Deng, M Zhou, T Liao, W Kuang, H Xia, Z Yin, Q Tan, Y Li, S Song, E Zhou, Y Jin |
Frontiers in Cell and Developmental Biology | 2022 |
Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types
B Tang, R Yan, J Zhu, S Cheng, C Kong, W Chen, S Fang, Y Wang, Y Yang, R Qiu, C Lu, J Ji |
International journal of biological sciences | 2022 |
Induction and application of ferroptosis in cancer therapy
Q Nie, Y Hu, X Yu, X Li, X Fang |
Cancer Cell International | 2022 |
Role of Ferroptosis in Stroke
Y Xu, K Li, Y Zhao, L Zhou, Y Liu, J Zhao |
Cellular and Molecular Neurobiology | 2022 |
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis
L Lin, M Zhang, L Zhang, D Zhang, C Li, Y Li |
Frontiers in Cell and Developmental Biology | 2022 |
Ferroptosis in cancer and cancer immunotherapy
L Zhao, X Zhou, F Xie, L Zhang, H Yan, J Huang, C Zhang, F Zhou, J Chen, L Zhang |
2022 | |
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
B Cakir, Y Tanaka, F Kiral, Y Xiang, O Dagliyan, J Wang, M Lee, A Greaney, W Yang, C duBoulay, M Kural, B Patterson, M Zhong, J Kim, Y Bai, W Min, L Niklason, P Patra, I Park |
Nature Communications | 2022 |
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
A Singh, A Raza, S Amin, C Damodaran, A Sharma |
Molecules (Basel, Switzerland) | 2022 |
Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway
L Zhang, C Li, Y Zhang, J Zhang, X Yang |
Oncology Letters | 2022 |
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
S Coillie, E San, I Goetschalckx, B Wiernicki, B Mukhopadhyay, W Tonnus, S Choi, R Roelandt, C Dumitrascu, L Lamberts, G Dams, W Weyts, J Huysentruyt, B Hassannia, I Ingold, S Lele, E Meyer, M Berg, R Seurinck, Y Saeys, A Vermeulen, A van Nuijs, M Conrad, A Linkermann, M Rajapurkar, P Vandenabeele, E Hoste, K Augustyns, T Berghe |
Nature Communications | 2022 |
CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma
L Qiu, R Zhou, Z Luo, J Wu, H Jiang |
Frontiers in Oncology | 2022 |
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
A Jo, J Bae, Y Yoon, T Chung, E Lee, Y Kim, H Joh, J Chung |
Cell Death and Disease | 2022 |
Targeting ferroptosis as a vulnerability in cancer
G Lei, L Zhuang, B Gan |
Nature Reviews Cancer | 2022 |
Ferroptosis Biology and Implication in Cancers
C Qu, Y Peng, S Liu |
Frontiers in Molecular Biosciences | 2022 |
Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells
S Pandrangi, P Chittineedi, S Chalumuri, A Meena, J Mosquera, S Llaguno, R Pamuru, G Mohiddin, A Mohammad |
Molecules (Basel, Switzerland) | 2022 |
Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis
C Feng, Y Wu, Y Chen, X Xiong, P Li, X Peng, C Li, W Weng, Y Zhu, D Zhou, Y Li |
Molecular Biology Reports | 2022 |
Regulatory pathways and drugs associated with ferroptosis in tumors
D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo, P Wu, X Deng, L Li, S Zuo, Q Yan, S Zhang, F Wang, L Shi, X Li, B Xiang, M Zhou, Q Liao, C Guo, Z Zeng, W Xiong, Z Gong |
Cell Death and Disease | 2022 |
Ferroptosis and Its Potential Role in the Nervous System Diseases
Zhou Y, Lin W, Rao T, Zheng J, Zhang T, Zhang M, Lin Z |
Journal of inflammation research | 2022 |
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity.
Wiernicki B, Maschalidi S, Pinney J, Adjemian S, Vanden Berghe T, Ravichandran KS, Vandenabeele P |
Nature Communications | 2022 |
Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma
Ferrada L, Barahona MJ, Salazar K, Godoy AS, Vera M, Nualart F |
Frontiers in Oncology | 2022 |
Iron Transporters and Ferroptosis in Malignant Brain Tumors
Zhao J, Wang Y, Tao L, Chen L |
Frontiers in Oncology | 2022 |
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1
Shi H, Hou B, Li H, Zhou H, Du B |
Frontiers in pharmacology | 2022 |
Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction
Liang X, Hu C, Han M, Liu C, Sun X, Yu K, Gu H, Zhang J |
Frontiers in Oncology | 2022 |
Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
Lai X, Sun Y, Zhang X, Wang D, Wang J, Wang H, Zhao Y, Liu X, Xu X, Song H, Ping W, Sun Y, Hu Z |
Frontiers in pharmacology | 2022 |
Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases
Cui C, Yang F, Li Q |
Frontiers in Molecular Biosciences | 2022 |
Ferroptosis-related local immune cytolytic activity in tumor microenvironment of basal cell and squamous cell carcinoma
Wang J, Xie D, Wu H, Li Y, Wan C |
Aging | 2022 |
Therapeutic Implications of Ferroptosis in Renal Fibrosis
Zhang Y, Mou Y, Zhang J, Suo C, Zhou H, Gu M, Wang Z, Tan R |
Frontiers in Molecular Biosciences | 2022 |
Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes
Kim DH, Choi HI, Park JS, Kim CS, Bae EH, Ma SK, Kim SW |
Redox Biology | 2022 |
Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment
de Souza I, Ramalho MC, Guedes CB, Osawa IY, Monteiro LK, Gomes LR, Rocha CR |
International journal of molecular sciences | 2022 |
Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines
Fernández-Acosta R, Iriarte-Mesa C, Alvarez-Alminaque D, Hassannia B, Wiernicki B, Díaz-García AM, Vandenabeele P, Vanden Berghe T, Pardo Andreu GL |
Molecules (Basel, Switzerland) | 2022 |
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation
de Souza I, Monteiro LK, Guedes CB, Silva MM, Andrade-Tomaz M, Contieri B, Latancia MT, Mendes D, Porchia BF, Lazarini M, Gomes LR, Rocha CR |
Cell Death and Disease | 2022 |
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra J, Kodavati M, Provasek VE, Rao KS, Mitra S, Hamilton DJ, Horner PJ, Vahidy FS, Britz GW, Kent TA, Hegde ML |
Ageing Research Reviews | 2022 |
Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers
Feng J, Wang J, Wang Y, Huang X, Shao T, Deng X, Cao Y, Zhou M, Zhao C |
Frontiers in Cell and Developmental Biology | 2022 |
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing
Pontel LB, Bueno-Costa A, Morellato AE, Carvalho Santos J, Roué G, Esteller M |
Redox Biology | 2022 |
Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field
Cheng K, Guo Q, Shen Z, Yang W, Zhou Y, Sun Z, Yao X, Wu H |
Frontiers in Oncology | 2022 |
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response
De Backer J, Maric D, Zuhra K, Bogaerts A, Szabo C, Vanden Berghe W, Hoogewijs D |
Antioxidants | 2022 |
Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer
Meng Y, Sun H, Li Y, Zhao S, Su J, Zeng F, Deng G, Chen X |
International journal of biological sciences | 2022 |
Ferroptosis-related gene signatures in neuroblastoma associated with prognosis
Chen Y, Li Z, Cao Q, Guan H, Mao L, Zhao M |
Frontiers in Cell and Developmental Biology | 2022 |
Microenvironment immune response induced by tumor ferroptosis—the application of nanomedicine
Yun T, Liu Z, Wang J, Wang R, Zhu L, Zhu Z, Wang X |
Frontiers in Oncology | 2022 |
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns.
Qu L, He X, Tang Q, Fan X, Liu J, Lin A |
Journal of Zhejiang University. Science. B | 2022 |
Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells.
Mi XJ, Park HR, Dhandapani S, Lee S, Kim YJ |
International journal of biological sciences | 2022 |
Ferroptosis Induction and YAP Inhibition as New Therapeutic Targets in Gastrointestinal Stromal Tumors (GISTs)
Delvaux M, Hagué P, Craciun L, Wozniak A, Demetter P, Schöffski P, Erneux C, Vanderwinden JM |
Cancers | 2022 |
Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer
Zhang M, Liu Z, Le Y, Gu Z, Zhao H |
Oxidative medicine and cellular longevity | 2022 |
The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
Zhang W, Li X, Xu J, Wang Y, Xing Z, Hu S, Fan Q, Lu S, Cheng J, Gu J, Cai R |
Cancers | 2022 |
Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis
Li Y, Zhu Z, Cui H, Ding K, Zhao Y, Ma X, Adetunji AO, Min L |
2022 | |
The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
Ma J, Zhang H, Chen Y, Liu X, Tian J, Shen W |
Biomolecules | 2022 |
Targeting lipid metabolism for ferroptotic cancer therapy.
Luo M, Yan J, Hu X, Li H, Li H, Liu Q, Chen Y, Zou Z |
Apoptosis : an international journal on programmed cell death | 2022 |
The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
Huo C, Li G, Hu Y, Sun H |
International journal of molecular sciences | 2022 |
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10
Chen W, Yang W, Zhang C, Liu T, Zhu J, Wang H, Li T, Jin A, Ding L, Xian J, Tian T, Pan B, Guo W, Wang B |
Oxidative medicine and cellular longevity | 2022 |
Functional Validation of the Putative Oncogenic Activity of PLAU
Sarno F, Goubert D, Logie E, Rutten MG, Koncz M, Deben C, Niemarkt AE, Altucci L, Verschure PJ, Kiss A, Berghe WV, Rots MG |
Biomedicines | 2022 |
Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers.
Rashad S, Byrne SR, Saigusa D, Xiang J, Zhou Y, Zhang L, Begley TJ, Tominaga T, Niizuma K |
Neuroscience | 2022 |
An iron-dependent form of non-canonical ferroptosis induced by labile iron.
Li Y, Ouyang Q, Chen W, Liu K, Zhang B, Yao J, Zhang S, Ding J, Cong M, Xu A |
Science China Life Sciences | 2022 |
Gene interfered-ferroptosis therapy for cancers
J Gao, T Luo, J Wang |
Nature Communications | 2021 |
Ferroptosis-mediated Crosstalk in the Tumor Microenvironment Implicated in Cancer Progression and Therapy
Y Liu, C Duan, R Dai, Y Zeng |
Frontiers in Cell and Developmental Biology | 2021 |
Ferroptosis: Mechanism and Diseases
AF Florez, H Alborzinia |
2021 | |
Ferroptosis: Mechanism and Diseases
AF Florez, H Alborzinia |
2021 | |
A Novel Ferroptosis-Associated Gene Signature to Predict Prognosis in Patients with Uveal Melanoma
H Luo, C Ma |
Diagnostics | 2021 |
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
W Liao, W Yang, Z Shen, W Ai, Q Pan, Y Sun, S Guo |
Diabetes | 2021 |
Ferroptosis: mechanisms and links with diseases
H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi, P Lei |
Signal Transduction and Targeted Therapy | 2021 |
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
V Consoli, V Sorrenti, S Grosso, L Vanella |
Biomolecules | 2021 |
Molecular mechanisms of cell death in neurological diseases
D Moujalled, A Strasser, JR Liddell |
Cell Death and Differentiation | 2021 |
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Z Tang, Y Ju, X Dai, N Ni, Y Liu, D Zhang, H Gao, H Sun, J Zhang, P Gu |
Redox Biology | 2021 |
The Multifaceted Regulation of Mitochondria in Ferroptosis
H Wu, F Wang, N Ta, T Zhang, W Gao |
Life Sciences | 2021 |
Emerging mechanisms and targeted therapy of ferroptosis in cancer
H Wang, Y Cheng, C Mao, S Liu, D Xiao, J Huang, Y Tao |
Molecular Therapy | 2021 |
Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism
JC Rodriguez-Gonzalez, I Hernández-Balmaseda, K Declerck, C Pérez-Novo, E Logie, C Theys, P Jakubek, OL Quiñones-Maza, G Dantas-Cassali, DC dos Reis, GV Camp, MT Paz, I Rodeiro-Guerra, R Delgado-Hernández, WV Berghe |
Frontiers in pharmacology | 2021 |
Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer
G Greco, E Catanzaro, C Fimognari |
Cancers | 2021 |
Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
R Das, A Rauf, S Akhter, MN Islam, TB Emran, S Mitra, IN Khan, MS Mubarak |
Molecules (Basel, Switzerland) | 2021 |
Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
R Huang, R Dong, N Wang, Y He, P Zhu, C Wang, B Lan, Y Gao, L Sun |
Cellular and Molecular Neurobiology | 2021 |
The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival
SK Chiang, SE Chen, LC Chang |
Cells | 2021 |
Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy
C Bartolacci, C Andreani, Y El-Gammal, PP Scaglioni |
Frontiers in Molecular Biosciences | 2021 |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Q Tan, Y Fang, Q Gu |
Frontiers in pharmacology | 2021 |
Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action
Y Fang, X Chen, Q Tan, H Zhou, J Xu, Q Gu |
ACS Central Science | 2021 |
Ferroptosis Meets Cell–Cell Contacts
C Dietrich, TG Hofmann |
Cells | 2021 |
Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage
MY Li, XH Dai, XP Yu, W Zou, W Teng, P Liu, XY Yu, Q An, X Wen |
Journal of Molecular Neuroscience | 2021 |
Ferroptosis: mechanisms, biology and role in disease
X Jiang, BR Stockwell, M Conrad |
Nature Reviews Molecular Cell Biology | 2021 |
Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation
VE Kagan, YY Tyurina, II Vlasova, AA Kapralov, AA Amoscato, TS Anthonymuthu, VA Tyurin, IH Shrivastava, FB Cinemre, A Lamade, MW Epperly, JS Greenberger, DH Beezhold, RK Mallampalli, AK Srivastava, H Bayir, AA Shvedova |
Frontiers in Endocrinology | 2021 |
Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice
X Feng, S Wang, Z Sun, H Dong, H Yu, M Huang, X Gao |
Frontiers in Endocrinology | 2021 |
Clinical Significance of Heme Oxygenase 1 in Tumor Progression
M Nitti, C Ivaldo, N Traverso, AL Furfaro |
Antioxidants | 2021 |
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
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Frontiers in Oncology | 2021 |
Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma
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Nature Communications | 2021 |
Nanoparticles for Ferroptosis Therapy in Cancer
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Pharmaceutics | 2021 |
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CNS Neuroscience & Therapeutics | 2021 |
Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
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Redox Biology | 2021 |
Epigenomic regulation by labile iron
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Free radical biology & medicine | 2021 |
Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells
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Frontiers in Cell and Developmental Biology | 2021 |
A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data
R Odongo, A Demiroglu-Zergeroglu, T Çakır |
2021 | |
Ferroptosis, radiotherapy, and combination therapeutic strategies
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Antioxidants | 2021 |
Ferroptosis Patterns Correlate with Immune Microenvironment Characterization in Gastric Cancer
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International journal of general medicine | 2021 |
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Biology : open access journal | 2021 |
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Nature Reviews Clinical Oncology | 2021 |
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
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International journal of biological sciences | 2021 |
Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma
JV Loenhout, LF Boullosa, D Quatannens, JD Waele, C Merlin, H Lambrechts, HW Lau, C Hermans, A Lin, F Lardon, M Peeters, A Bogaerts, E Smits, C Deben |
Cells | 2021 |
Research progress on the occurrence and therapeutic mechanism of ferroptosis in NSCLC
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Naunyn-Schmiedeberg's Archives of Pharmacology | 2021 |
Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular Senescence
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International journal of molecular sciences | 2021 |
Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1
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Cell Death Discovery | 2021 |
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International journal of molecular sciences | 2021 |
Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
M Dahlmanns, E Yakubov, JK Dahlmanns |
Frontiers in Oncology | 2021 |
Regulated cell death: discovery, features and implications for neurodegenerative diseases
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Cell Communication and Signaling | 2021 |
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Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
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Nature Communications | 2020 |
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway
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International journal of molecular sciences | 2020 |
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Biomarker Research | 2020 |
Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
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Antioxidants | 2020 |
Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells
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International journal of molecular sciences | 2020 |
Targeting apoptosis in cancer therapy
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Nature Reviews Clinical Oncology | 2020 |
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
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Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?
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Frontiers in Oncology | 2020 |
Ferroptosis in Cancer Treatment: Another Way to Rome
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Frontiers in Oncology | 2020 |
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Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers
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Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches
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Cell Chemical Biology | 2020 |
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
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ACS Nano | 2020 |
The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury
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Oxidative medicine and cellular longevity | 2020 |
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Emerging immune and cell death mechanisms in stroke: Saponins as therapeutic candidates
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Ferroptosis: molecular mechanisms and health implications
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Cell Research | 2020 |
Ferroptosis in Cancer Cell Biology
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Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease
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Neuropathology and Applied Neurobiology | 2020 |
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Frontiers in neuroscience | 2020 |
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Translational oncology | 2020 |
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Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
J Lippmann, K Petri, S Fulda, J Liese |
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Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression
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Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis
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Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology
RA Brown, KL Richardson, TD Kabir, D Trinder, R Ganss, PJ Leedman |
Frontiers in Oncology | 2020 |
Discovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo
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The Chemistry and Biology of Ferroptosis
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Cell Chemical Biology | 2020 |
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
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Cells | 2020 |
The pathological role of ferroptosis in ischemia/reperfusion-related injury
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Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib
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Frontiers in Oncology | 2020 |
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
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Nature Reviews Cancer | 2019 |
Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model
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Cells | 2019 |
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
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The chemical basis of ferroptosis
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Nature Chemical Biology | 2019 |
Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
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Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
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A Dual Role of Heme Oxygenase-1 in Cancer Cells
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International journal of molecular sciences | 2018 |
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